Scott Jacobson
Overview
Explore the profile of Scott Jacobson including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
191
Followers
0
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Recent Articles
1.
Jackson J, Shibuya G, Ravishankar B, Adusumilli L, Bradford D, Brockstedt D, et al.
J Med Chem
. 2022 Sep;
65(19):12895-12924.
PMID: 36127295
General control nonderepressible 2 (GCN2) protein kinase is a cellular stress sensor within the tumor microenvironment (TME), whose signaling cascade has been proposed to contribute to immune escape in tumors....
2.
Jorapur A, Marshall L, Jacobson S, Xu M, Marubayashi S, Zibinsky M, et al.
PLoS Pathog
. 2022 Jan;
18(1):e1010200.
PMID: 35025968
The Epstein-Barr Virus (EBV) is involved in the etiology of multiple hematologic and epithelial human cancers. EBV+ tumors employ multiple immune escape mechanisms, including the recruitment of immunosuppressive regulatory T...
3.
Marshall L, Marubayashi S, Jorapur A, Jacobson S, Zibinsky M, Robles O, et al.
J Immunother Cancer
. 2020 Nov;
8(2).
PMID: 33243932
Background: Checkpoint inhibitors (CPIs) such as anti-PD(L)-1 and anti-CTLA-4 antibodies have resulted in unprecedented rates of antitumor responses and extension of survival of patients with a variety of cancers. But...
4.
Ohol Y, Sun M, Cutler G, Leger P, Hu D, Biannic B, et al.
Mol Cancer Ther
. 2020 Aug;
19(10):1970-1980.
PMID: 32788207
The deubiquitinase USP7 regulates the levels of multiple proteins with roles in cancer progression and immune response. Thus, USP7 inhibition may decrease oncogene function, increase tumor suppressor function, and sensitize...
5.
Robles O, Jackson J, Marshall L, Talay O, Chian D, Cutler G, et al.
J Med Chem
. 2020 Jul;
63(15):8584-8607.
PMID: 32667798
The C-C chemokine receptor 4 (CCR4) is broadly expressed on regulatory T cells (T) as well as other circulating and tissue-resident T cells. T can be recruited to the tumor...
6.
Leger P, Hu D, Biannic B, Bui M, Han X, Karbarz E, et al.
J Med Chem
. 2020 Apr;
63(10):5398-5420.
PMID: 32302140
USP7 is a promising target for cancer therapy as its inhibition is expected to decrease function of oncogenes, increase tumor suppressor function, and enhance immune function. Using a structure-based drug...
7.
Jackson J, Ketcham J, Younai A, Abraham B, Biannic B, Beck H, et al.
J Med Chem
. 2019 Jul;
62(13):6190-6213.
PMID: 31259550
Recruitment of suppressive CD4 FOXP3 regulatory T cells (T) to the tumor microenvironment (TME) has the potential to weaken the antitumor response in patients receiving treatment with immuno-oncology (IO) agents....
8.
Diep B, Hilliard J, Le V, Tkaczyk C, Le H, Tran V, et al.
Antimicrob Agents Chemother
. 2017 Jan;
61(4).
PMID: 28115346
The role broad-spectrum antibiotics play in the spread of antimicrobial resistance, coupled with their effect on the healthy microbiome, has led to advances in pathogen-specific approaches for the prevention or...
9.
Churchill R, Chuinard C, Wiater J, Friedman R, Freehill M, Jacobson S, et al.
J Bone Joint Surg Am
. 2016 Apr;
98(7):552-60.
PMID: 27053583
Background: Stemmed humeral components have been used since the 1950s; canal-sparing (also known as stemless) humeral components became commercially available in Europe in 2004. The Simpliciti total shoulder system (Wright...
10.
Suguitan Jr A, Zengel J, Jacobson S, Gee S, Cetz J, Cha P, et al.
Influenza Other Respir Viruses
. 2014 Apr;
8(2):169-76.
PMID: 24734293
Objective: The objective was to study passively acquired influenza H1N1 pandemic (H1N1pdm) maternal antibody kinetics and its impact on subsequent influenza infection and vaccination in ferrets during an outbreak of...