Dirk G Brockstedt
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Explore the profile of Dirk G Brockstedt including associated specialties, affiliations and a list of published articles.
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36
Citations
2322
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Recent Articles
1.
Bissonnette R, DuBois J, Facheris P, Del Duca E, Kim M, Da Rosa J, et al.
Allergy
. 2023 Nov;
79(4):924-936.
PMID: 37984453
Background: RPT193 is an orally administered small molecule antagonist of the human C-C motif chemokine receptor 4 (CCR4) that inhibits the migration and downstream activation of T-helper Type 2 (Th2)...
2.
Jackson J, Shibuya G, Ravishankar B, Adusumilli L, Bradford D, Brockstedt D, et al.
J Med Chem
. 2022 Sep;
65(19):12895-12924.
PMID: 36127295
General control nonderepressible 2 (GCN2) protein kinase is a cellular stress sensor within the tumor microenvironment (TME), whose signaling cascade has been proposed to contribute to immune escape in tumors....
3.
Jorapur A, Marshall L, Jacobson S, Xu M, Marubayashi S, Zibinsky M, et al.
PLoS Pathog
. 2022 Jan;
18(1):e1010200.
PMID: 35025968
The Epstein-Barr Virus (EBV) is involved in the etiology of multiple hematologic and epithelial human cancers. EBV+ tumors employ multiple immune escape mechanisms, including the recruitment of immunosuppressive regulatory T...
4.
Marshall L, Marubayashi S, Jorapur A, Jacobson S, Zibinsky M, Robles O, et al.
J Immunother Cancer
. 2020 Nov;
8(2).
PMID: 33243932
Background: Checkpoint inhibitors (CPIs) such as anti-PD(L)-1 and anti-CTLA-4 antibodies have resulted in unprecedented rates of antitumor responses and extension of survival of patients with a variety of cancers. But...
5.
Ohol Y, Sun M, Cutler G, Leger P, Hu D, Biannic B, et al.
Mol Cancer Ther
. 2020 Aug;
19(10):1970-1980.
PMID: 32788207
The deubiquitinase USP7 regulates the levels of multiple proteins with roles in cancer progression and immune response. Thus, USP7 inhibition may decrease oncogene function, increase tumor suppressor function, and sensitize...
6.
Robles O, Jackson J, Marshall L, Talay O, Chian D, Cutler G, et al.
J Med Chem
. 2020 Jul;
63(15):8584-8607.
PMID: 32667798
The C-C chemokine receptor 4 (CCR4) is broadly expressed on regulatory T cells (T) as well as other circulating and tissue-resident T cells. T can be recruited to the tumor...
7.
Leger P, Hu D, Biannic B, Bui M, Han X, Karbarz E, et al.
J Med Chem
. 2020 Apr;
63(10):5398-5420.
PMID: 32302140
USP7 is a promising target for cancer therapy as its inhibition is expected to decrease function of oncogenes, increase tumor suppressor function, and enhance immune function. Using a structure-based drug...
8.
Tsujikawa T, Crocenzi T, Durham J, Sugar E, Wu A, Onners B, et al.
Clin Cancer Res
. 2020 Apr;
26(14):3578-3588.
PMID: 32273276
Purpose: Two studies in previously treated metastatic pancreatic cancer have been completed combining GVAX pancreas vaccine (GM-CSF-secreting allogeneic pancreatic tumor cells) with cyclophosphamide (Cy) and CRS-207 (live, attenuated -expressing mesothelin)....
9.
Nair N, Chen S, Lemmens E, Chang S, Le D, Jaffee E, et al.
Cancer Immunol Res
. 2020 Mar;
8(5):609-617.
PMID: 32132105
The identification of biomarkers for patient stratification is fundamental to precision medicine efforts in oncology. Here, we identified two baseline, circulating immune cell subsets associated with overall survival in patients...
10.
Hassan R, Alley E, Kindler H, Antonia S, Jahan T, Honarmand S, et al.
Clin Cancer Res
. 2019 Jul;
25(19):5787-5798.
PMID: 31263030
Purpose: Malignant pleural mesothelioma (MPM) is an aggressive cancer associated with poor prognosis. CRS-207 is a live-attenuated engineered to express mesothelin, a tumor-associated antigen highly expressed in MPM. CRS-207 induces...