Scott Houliston
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Explore the profile of Scott Houliston including associated specialties, affiliations and a list of published articles.
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30
Citations
762
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Recent Articles
1.
Wang X, Sun J, Ahmad S, Yang D, Li F, Chan U, et al.
bioRxiv
. 2025 Feb;
PMID: 39896675
We report an enantioselective protein affinity selection mass spectrometry screening approach (EAS-MS) that enables the detection of weak binders, informs about selectivity, and generates orthogonal confirmation of binding. After method...
2.
Mettu A, Glavatskikh M, Wang X, Lara Ordonez A, Li F, Chau I, et al.
Chem Sci
. 2025 Jan;
16(8):3430-3439.
PMID: 39877816
Critical Assessment of Computational Hit-Finding Experiments (CACHE) Challenges emerged as real-life stress tests for computational hit-finding strategies. In CACHE Challenge #1, 23 participants contributed their original workflows to identify small-molecule...
3.
Li F, Ackloo S, Arrowsmith C, Ban F, Barden C, Beck H, et al.
J Chem Inf Model
. 2024 Nov;
64(22):8521-8536.
PMID: 39499532
The CACHE challenges are a series of prospective benchmarking exercises to evaluate progress in the field of computational hit-finding. Here we report the results of the inaugural CACHE challenge in...
4.
Ackloo S, Li F, Szewczyk M, Seitova A, Loppnau P, Zeng H, et al.
J Med Chem
. 2024 Nov;
68(2):1092-1112.
PMID: 39495097
Target class-focused drug discovery has a strong track record in pharmaceutical research, yet public domain data indicate that many members of protein families remain unliganded. Here we present a systematic...
5.
Eguida M, Bret G, Sindt F, Li F, Chau I, Ackloo S, et al.
J Chem Inf Model
. 2024 Jun;
64(13):5344-5355.
PMID: 38916159
We herewith applied a generic hit identification method (POEM) for difficult targets of known three-dimensional structure, relying on the simple knowledge of physicochemical and topological properties of a user-selected cavity....
6.
Dudley J, Park S, Cho O, Wells N, MacDonald M, Blejec K, et al.
Protein Sci
. 2024 May;
33(6):e4991.
PMID: 38757381
The de novo design of miniprotein inhibitors has recently emerged as a new technology to create proteins that bind with high affinity to specific therapeutic targets. Their size, ease of...
7.
Yin J, Keszei A, Houliston S, Filandr F, Beenstock J, Daou S, et al.
Structure
. 2024 Mar;
32(6):795-811.e6.
PMID: 38531363
GCN2 is a stress response kinase that phosphorylates the translation initiation factor eIF2α to inhibit general protein synthesis when activated by uncharged tRNA and stalled ribosomes. The presence of a...
8.
Bhandari V, Reichheld S, Houliston S, Lemak A, Arrowsmith C, Sharpe S, et al.
J Biol Chem
. 2023 Sep;
299(10):105199.
PMID: 37660904
Regulatory ATPase variant A (RavA) is a MoxR AAA+ protein that functions together with a partner protein termed von Willebrand factor type A interacting with AAA+ ATPase (ViaA). RavA-ViaA are...
9.
Payliss B, Tse Y, Reichheld S, Lemak A, Yun H, Houliston S, et al.
Cell Rep
. 2022 Oct;
41(4):111537.
PMID: 36288699
The DNA repair scaffold SLX4 has multifaceted roles in genome stability, many of which depend on structure-selective endonucleases. SLX4 coordinates the cell cycle-regulated assembly of SLX1, MUS81-EME1, and XPF-ERCC1 into...
10.
Chidyausiku T, Mendes S, Klima J, Nadal M, Eckhard U, Roel-Touris J, et al.
Nat Commun
. 2022 Oct;
13(1):5661.
PMID: 36192397
Antibodies, and antibody derivatives such as nanobodies, contain immunoglobulin-like (Ig) β-sandwich scaffolds which anchor the hypervariable antigen-binding loops and constitute the largest growing class of drugs. Current engineering strategies for...