Scott D Rychnovsky
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Explore the profile of Scott D Rychnovsky including associated specialties, affiliations and a list of published articles.
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122
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1318
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Recent Articles
1.
Thompson J, Le N, Pluemer J, Chen R, Dooley 3rd C, Ziller J, et al.
J Org Chem
. 2025 Feb;
90(6):2493-2499.
PMID: 39908581
We previously demonstrated that osmium tetroxide and TMEDA generate stable crystalline adducts with alkenes that facilitate X-ray analysis and structure assignments. Alternatively, osmate esters can be prepared from diols, potassium...
2.
Wong C, Pazienza J, Rychnovsky S, Nizkorodov S
J Am Chem Soc
. 2024 Apr;
146(17):11702-11710.
PMID: 38640258
Sulfuric acid in the atmosphere can participate in acid-catalyzed and acid-driven reactions, including those within secondary organic aerosols (SOA). Previous studies have observed enhanced absorption at visible wavelengths and significant...
3.
Jiao F, Salituro L, Yu C, Gutierrez C, Rychnovsky S, Huang L
Anal Chem
. 2023 Jan;
95(4):2532-2539.
PMID: 36652389
The development of MS-cleavable cross-linking mass spectrometry (XL-MS) has enabled the effective capture and identification of endogenous protein-protein interactions (PPIs) and their residue contacts at the global scale without cell...
4.
Dooley 3rd C, Rychnovsky S
Org Lett
. 2022 May;
24(18):3411-3415.
PMID: 35499304
We report the first total synthesis of (2)-hydroxynorneomajucin, a norsesquiterpene derived from the genus. This natural product displays neurotrophic properties. Small molecule neurotrophins have potential as therapeutics in neurodegenerative diseases....
5.
Jiao F, Yu C, Wheat A, Wang X, Rychnovsky S, Huang L
Anal Chem
. 2022 Mar;
94(10):4236-4242.
PMID: 35235311
Cross-linking mass spectrometry (XL-MS) is an emergent technology for studying protein-protein interactions (PPIs) and elucidating architectures of protein complexes. The development of various MS-cleavable cross-linkers has facilitated the identification of...
6.
Salituro L, Pazienza J, Rychnovsky S
Org Lett
. 2022 Jan;
24(5):1190-1194.
PMID: 35094508
We report the first total syntheses of strasseriolide A and B. Strasseriolide B shows potent activity against the wild-type malaria parasite and good activity against a chloroquine-resistant strain. A convergent...
7.
Wheat A, Yu C, Wang X, Burke A, Chemmama I, Kaake R, et al.
Proc Natl Acad Sci U S A
. 2021 Aug;
118(32).
PMID: 34349018
Defining protein-protein interactions (PPIs) in their native environment is crucial to understanding protein structure and function. Cross-linking-mass spectrometry (XL-MS) has proven effective in capturing PPIs in living cells; however, the...
8.
Gutierrez C, Salituro L, Yu C, Wang X, DePeter S, Rychnovsky S, et al.
Mol Cell Proteomics
. 2021 Apr;
20:100084.
PMID: 33915260
Cross-linking mass spectrometry (XL-MS) is a powerful tool for studying protein-protein interactions and elucidating architectures of protein complexes. While residue-specific XL-MS studies have been very successful, accessibility of interaction regions...
9.
Carlson P, Burns A, Shimizu E, Wang S, Rychnovsky S
Org Lett
. 2021 Feb;
23(6):2183-2188.
PMID: 33635083
The utility of the dioxasiline ring as a π-facial directing group in the intramolecular Diels-Alder cyclization is explored. An initial investigation of substrate scope demonstrates that the rigidity of this...
10.
Dooley 3rd C, Burtea A, Mitilian C, Dao W, Qu B, Salzameda N, et al.
J Org Chem
. 2020 Aug;
85(16):10750-10759.
PMID: 32806106
The competing enantioselective conversion (CEC) method is a quick and reliable means to determine absolute configuration. Previously, Bode's chiral acylated hydroxamic acids were used to determine the stereochemistry of primary...