Danielle Vellucci
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Explore the profile of Danielle Vellucci including associated specialties, affiliations and a list of published articles.
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7
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348
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Recent Articles
1.
Kandur W, Kao A, Vellucci D, Huang L, Rychnovsky S
Org Biomol Chem
. 2015 Aug;
13(38):9793-807.
PMID: 26269432
The cross-linking Mass Spectrometry (XL-MS) technique has enormous potential for studying the interactions between proteins, and it can provide detailed structural information about the interaction interfaces in large protein complexes....
2.
Burke A, Kandur W, Novitsky E, Kaake R, Yu C, Kao A, et al.
Org Biomol Chem
. 2015 Apr;
13(17):5030-7.
PMID: 25823605
The cross-linking Mass Spectrometry (XL-MS) technique extracts structural information from protein complexes without requiring highly purified samples, crystallinity, or large amounts of material. However, there are challenges to applying the...
3.
Kaake R, Wang X, Burke A, Yu C, Kandur W, Yang Y, et al.
Mol Cell Proteomics
. 2014 Sep;
13(12):3533-43.
PMID: 25253489
Protein-protein interactions (PPIs) are fundamental to the structure and function of protein complexes. Resolving the physical contacts between proteins as they occur in cells is critical to uncovering the molecular...
4.
Mittapalli G, Vellucci D, Yang J, Toussaint M, Brothers S, Wahlestedt C, et al.
Bioorg Med Chem Lett
. 2012 May;
22(12):3916-20.
PMID: 22607676
Highly potent and selective small molecule neuropeptide Y Y2 receptor antagonists are reported. The systematic SAR exploration of a hit molecule N-(4-ethoxyphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide, identified from HTS, led to the discovery of...
5.
Kao A, Chiu C, Vellucci D, Yang Y, Patel V, Guan S, et al.
Mol Cell Proteomics
. 2010 Aug;
10(1):M110.002212.
PMID: 20736410
Knowledge of elaborate structures of protein complexes is fundamental for understanding their functions and regulations. Although cross-linking coupled with mass spectrometry (MS) has been presented as a feasible strategy for...
6.
Vellucci D, Kao A, Kaake R, Rychnovsky S, Huang L
J Am Soc Mass Spectrom
. 2010 May;
21(8):1432-45.
PMID: 20472459
Protein-protein interaction is one of the key regulatory mechanisms for controlling protein function in various cellular processes. Chemical cross-linking coupled with mass spectrometry has proven to be a powerful method...
7.
Vellucci D, Rychnovsky S
Org Lett
. 2007 Feb;
9(4):711-4.
PMID: 17286378
The reductive cyclization reaction of a cyanoacetal has been used to prepare the pectenotoxin 2 (PTX-2) AB spiroacetal with high diastereoselectively for the first time. The strategy is convergent and...