Scott D Rychnovsky
Overview
Explore the profile of Scott D Rychnovsky including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
122
Citations
1318
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Yu C, Novitsky E, Cheng N, Rychnovsky S, Huang L
Anal Chem
. 2020 Mar;
92(8):6026-6033.
PMID: 32202417
Cross-linking mass spectrometry (XL-MS) has become a powerful structural tool for defining protein-protein interactions (PPIs) and elucidating architectures of large protein assemblies. To advance XL-MS studies, we have previously developed...
12.
Gutierrez C, Chemmama I, Mao H, Yu C, Echeverria I, Block S, et al.
Proc Natl Acad Sci U S A
. 2020 Feb;
117(8):4088-4098.
PMID: 32034103
The COP9 signalosome (CSN) is an evolutionarily conserved eight-subunit (CSN1-8) protein complex that controls protein ubiquitination by deneddylating Cullin-RING E3 ligases (CRLs). The activation and function of CSN hinges on...
13.
Burns A, Dooley 3rd C, Carlson P, Ziller J, Rychnovsky S
Org Lett
. 2019 Dec;
21(24):10125-10129.
PMID: 31820648
Osmium tetroxide and TMEDA form stable crystalline adducts with alkenes. The structure of liquid alkenes can be determined through the X-ray analysis of these derivatives. Osmium, a heavy atom, facilitates...
14.
Burtea A, DeForest J, Li X, Rychnovsky S
Angew Chem Int Ed Engl
. 2019 Sep;
58(45):16193-16197.
PMID: 31491044
(-)-Himeradine A is a complex lycopodium alkaloid with seven rings and ten stereogenic centers that shows anticancer activity against lymphoma L1210 cells. A total synthesis has been developed that builds...
15.
Burns A, Rychnovsky S
J Am Chem Soc
. 2019 Aug;
141(34):13295-13300.
PMID: 31408328
Illisimonin A was isolated from and has a previously unreported tricyclic carbon framework. It displayed neuroprotective effects against oxygen-glucose deprivation-induced cell injury in SH-SY5Y cells. It incorporates a highly strained...
16.
Yu C, Wang X, Huszagh A, Viner R, Novitsky E, Rychnovsky S, et al.
Mol Cell Proteomics
. 2019 Feb;
18(5):954-967.
PMID: 30723094
Cytotoxic protein aggregation-induced impairment of cell function and homeostasis are hallmarks of age-related neurodegenerative pathologies. As proteasomal degradation represents the major clearance pathway for oxidatively damaged proteins, a detailed understanding...
17.
Burtea A, Rychnovsky S
Org Lett
. 2018 Sep;
20(18):5849-5852.
PMID: 30192149
A new biosynthesis was proposed for the kujounins A and A beginning from ascorbic acid, which in turn inspired a synthetic approach to kujounin A. The ring system was assembled...
18.
DeForest J, Samame R, Suryn G, Burtea A, Rychnovsky S
J Org Chem
. 2018 Jun;
83(16):8914-8925.
PMID: 29943989
(+)-Fastigiatine is a complex alkaloid isolated from the alpine club moss Lycopodium fastigatum, most commonly found in New Zealand. It has been the subject of two successful synthetic campaigns. A...
19.
Brito G, Della-Felice F, Luo G, Burns A, Pilli R, Rychnovsky S, et al.
Org Lett
. 2018 Jun;
20(13):4144-4147.
PMID: 29938513
Cyclometalated π-allyliridium C,O-benzoates modified by ( S)-SEGPHOS or ( S)-Cl,OMe-BIPHEP catalyze enantioselective 2-propanol-mediated reductive couplings of diverse nonmetallic allyl pronucleophiles with the acetylenic aldehyde TIPSC≡CCHO. Absolute stereochemistries of the resulting...
20.
Gutierrez C, Block S, Yu C, Soohoo S, Huszagh A, Rychnovsky S, et al.
Anal Chem
. 2018 May;
90(12):7600-7607.
PMID: 29792801
Cross-linking mass spectrometry (XL-MS) has become an emerging technology for defining protein-protein interactions (PPIs) and elucidating architectures of large protein complexes. Up to now, the most widely used cross-linking reagents...