Scott Christley
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Explore the profile of Scott Christley including associated specialties, affiliations and a list of published articles.
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55
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1760
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Recent Articles
1.
Hein D, Christie A, Holcomb M, Xie B, Jain A, Vento J, et al.
medRxiv
. 2025 Feb;
PMID: 39990557
Background: Extracting structured data from free-text medical records is laborious and error-prone. Traditional rule-based and early neural network methods often struggle with domain complexity and require extensive tuning. Large language...
2.
Smith C, Telesford K, Piccirillo S, Licon-Munoz Y, Zhang W, Tse K, et al.
J Neuroinflammation
. 2024 Jun;
21(1):161.
PMID: 38915059
Background: Pediatric acute transverse myelitis (ATM) accounts for 20-30% of children presenting with a first acquired demyelinating syndrome (ADS) and may be the first clinical presentation of a relapsing ADS...
3.
Monson N, Smith C, Greenberg H, Plumb P, Guzman A, Tse K, et al.
J Immunol
. 2023 Sep;
211(9):1332-1339.
PMID: 37712756
Pediatric and adult autoimmune encephalitis (AE) are often associated with Abs to the NR1 subunit of the N-methyl-d-aspartate (NMDA) receptor (NMDAR). Very little is known regarding the cerebrospinal fluid humoral...
4.
Zhang W, Joshi C, Smith C, Ujas T, Rivas J, Cowell L, et al.
J Immunol Methods
. 2023 Aug;
521:113535.
PMID: 37558123
Low pH stress and its influence on antibody binding is a common consideration among chemists, but is only recently emerging as a consideration in Immunological studies. Antibody characterizations in Multiple...
5.
Pavlovic M, Scheffer L, Motwani K, Kanduri C, Kompova R, Vazov N, et al.
Nat Mach Intell
. 2023 Jul;
3(11):936-944.
PMID: 37396030
Adaptive immune receptor repertoires (AIRR) are key targets for biomedical research as they record past and ongoing adaptive immune responses. The capacity of machine learning (ML) to identify complex discriminative...
6.
Lees W, Christley S, Peres A, Kos J, Corrie B, Ralph D, et al.
Immunoinformatics (Amst)
. 2023 Jun;
10.
PMID: 37388275
Analysis of an individual's immunoglobulin or T cell receptor gene repertoire can provide important insights into immune function. High-quality analysis of adaptive immune receptor repertoire sequencing data depends upon accurate...
7.
Ostmeyer J, Cowell L, Christley S
PLoS One
. 2023 Mar;
18(3):e0265313.
PMID: 36881590
Most statistical classifiers are designed to find patterns in data where numbers fit into rows and columns, like in a spreadsheet, but many kinds of data do not conform to...
8.
Corrie B, Christley S, Busse C, Cowell L, Neller K, Rubelt F, et al.
Methods Mol Biol
. 2022 May;
2453:447-476.
PMID: 35622339
High-throughput sequencing of adaptive immune receptor repertoires (AIRR, i.e., IG and TR ) has revolutionized the ability to study the adaptive immune response via large-scale experiments. Since 2009, AIRR sequencing...
9.
Christley S, Stervbo U, Cowell L
Methods Mol Biol
. 2022 May;
2453:439-446.
PMID: 35622338
AIRR-seq data sets are usually large and require specialized analysis methods and software tools. A typical Illumina MiSeq sequencing run generates 20-30 million 2 × 300 bp paired-end sequence reads,...
10.
Joshi C, Sivaprakasam K, Christley S, Ireland S, Rivas J, Zhang W, et al.
Neurol Neuroimmunol Neuroinflamm
. 2021 Dec;
9(1).
PMID: 34848502
Background And Objectives: Patients with Alzheimer dementia display evidence of amyloid-related neurodegeneration. Our focus was to determine whether such patients also display evidence of a disease-targeting adaptive immune response mediated...