Jared Ostmeyer
Overview
Explore the profile of Jared Ostmeyer including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
476
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Recent Articles
1.
Ostmeyer J, Park J, von Itzstein M, Hsiehchen D, Fattah F, Gwin M, et al.
J Immunother Cancer
. 2023 Aug;
11(8).
PMID: 37580069
Background: Immune checkpoint inhibitor (ICI) therapies may cause unpredictable and potentially severe autoimmune toxicities termed immune-related adverse events (irAEs). Because T cells mediate ICI effects, T cell profiling may provide...
2.
Ostmeyer J, Cowell L, Christley S
PLoS One
. 2023 Mar;
18(3):e0265313.
PMID: 36881590
Most statistical classifiers are designed to find patterns in data where numbers fit into rows and columns, like in a spreadsheet, but many kinds of data do not conform to...
3.
von Itzstein M, Gonugunta A, Sheffield T, Homsi J, Dowell J, Koh A, et al.
Cancers (Basel)
. 2022 Mar;
14(5).
PMID: 35267634
Antibiotic administration is associated with worse clinical outcomes and changes to the gut microbiome in cancer patients receiving immune checkpoint inhibitors (ICI). However, the effects of antibiotics on systemic immune...
4.
Ostmeyer J, Cowell L, Greenberg B, Christley S
Genes Immun
. 2021 Jun;
22(3):187-193.
PMID: 34127826
Each T cell receptor (TCR) gene is created without regard for which substances (antigens) the receptor can recognize. T cell selection culls developing T cells when their TCRs (i) fail...
5.
Ahmed M, von Itzstein M, Sheffield T, Khan S, Fattah F, Park J, et al.
J Immunother Cancer
. 2021 Jun;
9(6).
PMID: 34127546
Background: Increased body mass index (BMI) has been associated with improved response to immune checkpoint inhibitors (ICIs) in multiple cancer types. We evaluated associations between BMI, ICI dosing strategy, and...
6.
Christley S, Ostmeyer J, Quirk L, Zhang W, Sirak B, Giuliano A, et al.
Front Immunol
. 2021 Apr;
12:624230.
PMID: 33868241
Cervical cancer is the fourth most common cancer and fourth leading cause of cancer death among women worldwide. In low Human Development Index settings, it ranks second. Screening and surveillance...
7.
Ostmeyer J, Lucas E, Christley S, Lea J, Monson N, Tiro J, et al.
PLoS One
. 2020 Mar;
15(3):e0229569.
PMID: 32134923
We previously showed, in a pilot study with publicly available data, that T cell receptor (TCR) repertoires from tumor infiltrating lymphocytes (TILs) could be distinguished from adjacent healthy tissue repertoires...
8.
Ostmeyer J, Cowell L
Neurocomputing (Amst)
. 2019 Feb;
331:281-288.
PMID: 30799908
Recurrent Neural Networks (RNN) are a type of statistical model designed to handle sequential data. The model reads a sequence one symbol at a time. Each symbol is processed based...
9.
Ostmeyer J, Christley S, Toby I, Cowell L
Cancer Res
. 2019 Jan;
79(7):1671-1680.
PMID: 30622114
Immune repertoire deep sequencing allows comprehensive characterization of antigen receptor-encoding genes in a lymphocyte population. We hypothesized that this method could enable a novel approach to diagnose disease by identifying...
10.
Li J, Ostmeyer J, Cuello L, Perozo E, Roux B
J Gen Physiol
. 2018 Aug;
150(10):1408-1420.
PMID: 30072373
C-type inactivation is a time-dependent process observed in many K channels whereby prolonged activation by an external stimulus leads to a reduction in ionic conduction. While C-type inactivation is thought...