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Gary An

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Articles 115
Citations 2033
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Recent Articles
1.
Niarakis A, Laubenbacher R, An G, Ilan Y, Fisher J, Flobak A, et al.
NPJ Syst Biol Appl . 2024 Nov; 10(1):141. PMID: 39616158
Digital twins represent a key technology for precision health. Medical digital twins consist of computational models that represent the health state of individual patients over time, enabling optimal therapeutics and...
2.
Ingason A, Galenkamp A, Jonsdottir F, An G, Sigurdsson M
J Am Coll Surg . 2024 Oct; 240(1):73-81. PMID: 39431619
Background: Overall, 3% to 12% of opioid-naive patients develop persistent opioid use after surgery. It is still unclear whether persistent opioid use after transabdominal surgery is associated with adverse surgical...
3.
Cockrell C, Vodovotz Y, Zamora R, An G
bioRxiv . 2024 Jun; PMID: 38895374
Volumetric Muscle Loss (VML) injuries are characterized by significant loss of muscle mass, usually due to trauma or surgical resection, often with a residual open wound in clinical settings and...
4.
An G, Cockrell C
ArXiv . 2024 May; PMID: 38764598
On December 15, 2023, The National Academies of Sciences, Engineering and Medicine (NASEM) released a report entitled: "Foundational Research Gaps and Future Directions for Digital Twins." The ostensible purpose of...
5.
Laubenbacher R, Adler F, An G, Castiglione F, Eubank S, Fonseca L, et al.
Front Digit Health . 2024 Mar; 6:1349595. PMID: 38515550
A fundamental challenge for personalized medicine is to capture enough of the complexity of an individual patient to determine an optimal way to keep them healthy or restore their health....
6.
Laubenbacher R, Adler F, An G, Castiglione F, Eubank S, Fonseca L, et al.
NPJ Syst Biol Appl . 2024 Feb; 10(1):19. PMID: 38365857
Medical digital twins are computational models of human biology relevant to a given medical condition, which are tailored to an individual patient, thereby predicting the course of disease and individualized...
7.
Shin B, An G, Cockrell R
PLoS Comput Biol . 2024 Jan; 20(1):e1011776. PMID: 38261584
Introduction: B-cells are essential components of the immune system that neutralize infectious agents through the generation of antigen-specific antibodies and through the phagocytic functions of naïve and memory B-cells. However,...
8.
Feuerwerker S, Cockrell R, An G
Surg Infect (Larchmt) . 2023 Oct; 24(8):725-733. PMID: 37824803
There is increasing recognition of extensive crosstalk between programmed cell death pathways (PCDPs), such as apoptosis, pyroptosis, and necroptosis, resulting in a highly redundant system responsive to a breadth of...
9.
Marassi C, Socia D, Larie D, An G, Cockrell R
Surg Open Sci . 2023 Oct; 16:77-81. PMID: 37818461
Background: Though governed by the same underlying biology, the differential physiology of children causes the temporal evolution from health to a septic/diseased state to follow trajectories that are distinct from...
10.
Feuerwerker S, Kambli R, Grinberg D, Malhotra A, An G
Surg Open Sci . 2023 Oct; 16:94-97. PMID: 37808421
Background: Acute cholecystitis in patients on anti-thrombotic therapy (ATT) presents a clinical dilemma at the intersection between conflicting guidelines, specifically between timing of early operative management (OM) versus time-to-reversal of...