Scott C Ritchie
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Explore the profile of Scott C Ritchie including associated specialties, affiliations and a list of published articles.
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29
Citations
1446
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Recent Articles
1.
Tokolyi A, Persyn E, Nath A, Burnham K, Marten J, Vanderstichele T, et al.
Nat Genet
. 2025 Mar;
57(3):616-625.
PMID: 40038547
The biological mechanisms through which most nonprotein-coding genetic variants affect disease risk are unknown. To investigate gene-regulatory mechanisms, we mapped blood gene expression and splicing quantitative trait loci (QTLs) through...
2.
Loesch D, Garg M, Matelska D, Vitsios D, Jiang X, Ritchie S, et al.
Nat Commun
. 2025 Mar;
16(1):2124.
PMID: 40032831
Genomics can provide insight into the etiology of type 2 diabetes and its comorbidities, but assigning functionality to non-coding variants remains challenging. Polygenic scores, which aggregate variant effects, can uncover...
3.
4.
Liang Y, Lim C, Ritchie S, Bertin N, Chai J, Yao J, et al.
J Clin Endocrinol Metab
. 2025 Jan;
PMID: 39842943
Context: Type 2 diabetes (T2D) is a major global concern, with Asia at its epicenter in recent years. Proteins, products of gene transcription, serve as dynamic biomarkers for pinpointing perturbed...
5.
Lambert S, Wingfield B, Gibson J, Gil L, Ramachandran S, Yvon F, et al.
Nat Genet
. 2024 Sep;
56(10):1989-1994.
PMID: 39327485
No abstract available.
6.
Ritchie S, Taylor H, Liang Y, Manikpurage H, Pennells L, Foguet C, et al.
medRxiv
. 2024 Sep;
PMID: 39228710
Combining information from multiple GWASs for a disease and its risk factors has proven a powerful approach for development of polygenic risk scores (PRSs). This may be particularly useful for...
7.
Ritchie S, Inouye M
Nat Cardiovasc Res
. 2024 Aug;
1(2):102-103.
PMID: 39195987
No abstract available.
8.
Lambert S, Wingfield B, Gibson J, Gil L, Ramachandran S, Yvon F, et al.
medRxiv
. 2024 Jun;
PMID: 38853961
Polygenic scores (PGS) have transformed human genetic research and have multiple potential clinical applications, including risk stratification for disease prevention and prediction of treatment response. Here, we present a series...
9.
Liu Y, Ritchie S, Teo S, Ruuskanen M, Kambur O, Zhu Q, et al.
Nat Aging
. 2024 Mar;
4(4):584-594.
PMID: 38528230
Multiomics has shown promise in noninvasive risk profiling and early detection of various common diseases. In the present study, in a prospective population-based cohort with ~18 years of e-health record...
10.
Qin Y, Havulinna A, Liu Y, Jousilahti P, Ritchie S, Tokolyi A, et al.
Nat Genet
. 2024 Feb;
56(3):554.
PMID: 38424462
No abstract available.