Scott C Blanchard
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Explore the profile of Scott C Blanchard including associated specialties, affiliations and a list of published articles.
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129
Citations
7715
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Recent Articles
11.
Levring J, Terry D, Kilic Z, Fitzgerald G, Blanchard S, Chen J
Nature
. 2023 Mar;
616(7957):606-614.
PMID: 36949202
The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel that regulates salt and fluid homeostasis across epithelial membranes. Alterations in CFTR cause cystic fibrosis, a fatal disease without...
12.
Martin M, Pati A, Abeywickrama C, Bar S, Kilic Z, Altman R, et al.
J Phys Org Chem
. 2023 Jan;
36(1).
PMID: 36590885
No abstract available.
13.
Juette M, Carelli J, Rundlet E, Brown A, Shao S, Ferguson A, et al.
Elife
. 2022 Oct;
11.
PMID: 36264623
Rapid and accurate mRNA translation requires efficient codon-dependent delivery of the correct aminoacyl-tRNA (aa-tRNA) to the ribosomal A site. In mammals, this fidelity-determining reaction is facilitated by the GTPase elongation...
14.
Wang H, Yang H, Holm M, Tom H, Oltion K, Qatran Al-Khdhairawi A, et al.
Nat Chem
. 2022 Sep;
14(12):1443-1450.
PMID: 36123449
Ternatin-family cyclic peptides inhibit protein synthesis by targeting the eukaryotic elongation factor-1α. A potentially related cytotoxic natural product ('A3') was isolated from Aspergillus, but only 4 of its 11 stereocentres...
15.
Nishima W, Girodat D, Holm M, Rundlet E, Alejo J, Fischer K, et al.
Nucleic Acids Res
. 2022 Jul;
50(14):8302-8320.
PMID: 35808938
Translocation of messenger RNA (mRNA) and transfer RNA (tRNA) substrates through the ribosome during protein synthesis, an exemplar of directional molecular movement in biology, entails a complex interplay of conformational,...
16.
Wieland M, Holm M, Rundlet E, Morici M, Koller T, Maviza T, et al.
Proc Natl Acad Sci U S A
. 2022 May;
119(19):e2114214119.
PMID: 35500116
Argyrins are a family of naturally produced octapeptides that display promising antimicrobial activity against Pseudomonas aeruginosa. Argyrin B (ArgB) has been shown to interact with an elongated form of the...
17.
Asher W, Terry D, Gregorio G, Kahsai A, Borgia A, Xie B, et al.
Cell
. 2022 Apr;
185(10):1661-1675.e16.
PMID: 35483373
β-arrestins bind G protein-coupled receptors to terminate G protein signaling and to facilitate other downstream signaling pathways. Using single-molecule fluorescence resonance energy transfer imaging, we show that β-arrestin is strongly...
18.
Ciftci D, Martens C, Ghani V, Blanchard S, Politis A, Huysmans G, et al.
Proc Natl Acad Sci U S A
. 2021 Dec;
118(49).
PMID: 34873050
Transporters cycle through large structural changes to translocate molecules across biological membranes. The temporal relationships between these changes and function, and the molecular properties setting their rates, determine transport efficiency-yet...
19.
Pan M, Wright W, Chapple R, Zubair A, Sandhu M, Batchelder J, et al.
Nat Commun
. 2021 Nov;
12(1):6468.
PMID: 34753908
Survival in high-risk pediatric neuroblastoma has remained around 50% for the last 20 years, with immunotherapies and targeted therapies having had minimal impact. Here, we identify the small molecule CX-5461...
20.
Rundlet E, Holm M, Schacherl M, Natchiar S, Altman R, Spahn C, et al.
Nature
. 2021 Jul;
595(7869):741-745.
PMID: 34234344
Peptide-chain elongation during protein synthesis entails sequential aminoacyl-tRNA selection and translocation reactions that proceed rapidly (2-20 per second) and with a low error rate (around 10 to 10 at each...