Mikael Holm
Overview
Explore the profile of Mikael Holm including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
16
Citations
355
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Holm M, Natchiar S, Rundlet E, Myasnikov A, Watson Z, Altman R, et al.
Nature
. 2023 Apr;
617(7959):200-207.
PMID: 37020024
In all species, ribosomes synthesize proteins by faithfully decoding messenger RNA (mRNA) nucleotide sequences using aminoacyl-tRNA substrates. Current knowledge of the decoding mechanism derives principally from studies on bacterial systems....
2.
Juette M, Carelli J, Rundlet E, Brown A, Shao S, Ferguson A, et al.
Elife
. 2022 Oct;
11.
PMID: 36264623
Rapid and accurate mRNA translation requires efficient codon-dependent delivery of the correct aminoacyl-tRNA (aa-tRNA) to the ribosomal A site. In mammals, this fidelity-determining reaction is facilitated by the GTPase elongation...
3.
Wang H, Yang H, Holm M, Tom H, Oltion K, Qatran Al-Khdhairawi A, et al.
Nat Chem
. 2022 Sep;
14(12):1443-1450.
PMID: 36123449
Ternatin-family cyclic peptides inhibit protein synthesis by targeting the eukaryotic elongation factor-1α. A potentially related cytotoxic natural product ('A3') was isolated from Aspergillus, but only 4 of its 11 stereocentres...
4.
Nishima W, Girodat D, Holm M, Rundlet E, Alejo J, Fischer K, et al.
Nucleic Acids Res
. 2022 Jul;
50(14):8302-8320.
PMID: 35808938
Translocation of messenger RNA (mRNA) and transfer RNA (tRNA) substrates through the ribosome during protein synthesis, an exemplar of directional molecular movement in biology, entails a complex interplay of conformational,...
5.
Wieland M, Holm M, Rundlet E, Morici M, Koller T, Maviza T, et al.
Proc Natl Acad Sci U S A
. 2022 May;
119(19):e2114214119.
PMID: 35500116
Argyrins are a family of naturally produced octapeptides that display promising antimicrobial activity against Pseudomonas aeruginosa. Argyrin B (ArgB) has been shown to interact with an elongated form of the...
6.
Rundlet E, Holm M, Schacherl M, Natchiar S, Altman R, Spahn C, et al.
Nature
. 2021 Jul;
595(7869):741-745.
PMID: 34234344
Peptide-chain elongation during protein synthesis entails sequential aminoacyl-tRNA selection and translocation reactions that proceed rapidly (2-20 per second) and with a low error rate (around 10 to 10 at each...
7.
Kim C, Holm M, Mandava C, Sanyal S
RNA Biol
. 2021 May;
18(12):2363-2375.
PMID: 33938388
Kinetic characterization of ribosomal translocation is important for understanding the mechanism of elongation in protein synthesis. Here we have optimized a popular fluorescent-mRNA based translocation assay conducted in stopped-flow, by...
8.
Morse J, Girodat D, Burnett B, Holm M, Altman R, Sanbonmatsu K, et al.
Proc Natl Acad Sci U S A
. 2020 Feb;
117(7):3610-3620.
PMID: 32024753
The substrate for ribosomes actively engaged in protein synthesis is a ternary complex of elongation factor Tu (EF-Tu), aminoacyl-tRNA (aa-tRNA), and GTP. EF-Tu plays a critical role in mRNA decoding...
9.
McMahon M, Contreras A, Holm M, Uechi T, Forester C, Pang X, et al.
Elife
. 2019 Sep;
8.
PMID: 31478838
Small nucleolar RNAs (snoRNAs) are a diverse group of non-coding RNAs that direct chemical modifications at specific residues on other RNA molecules, primarily on ribosomal RNA (rRNA). SnoRNAs are altered...
10.
Holm M, Mandava C, Ehrenberg M, Sanyal S
Elife
. 2019 Jun;
8.
PMID: 31172942
Applying pre-steady state kinetics to an based reconstituted translation system, we have studied how the antibiotic viomycin affects the accuracy of genetic code reading. We find that viomycin binds to...