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Christopher Wostenberg

Explore the profile of Christopher Wostenberg including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
1.
Wostenberg C, Ceres P, Polaski J, Batey R
J Mol Biol . 2015 Sep; 427(22):3473-3490. PMID: 26343759
RNA folding in vivo is significantly influenced by transcription, which is not necessarily recapitulated by Mg(2+)-induced folding of the corresponding full-length RNA in vitro. Riboswitches that regulate gene expression at...
2.
Quarles K, Sahu D, Havens M, Forsyth E, Wostenberg C, Hastings M, et al.
Biochemistry . 2013 Jan; 52(5):795-807. PMID: 23305493
Most noncoding RNAs function properly only when folded into complex three-dimensional (3D) structures, but the experimental determination of these structures remains challenging. Understanding of primary microRNA (miRNA) maturation is currently...
3.
Wostenberg C, Lary J, Sahu D, Acevedo R, Quarles K, Cole J, et al.
PLoS One . 2012 Dec; 7(12):e51829. PMID: 23272173
One of the most exciting recent developments in RNA biology has been the discovery of small non-coding RNAs that affect gene expression through the RNA interference (RNAi) mechanism. Two major...
4.
Wostenberg C, Kumar S, Noid W, Showalter S
J Phys Chem B . 2011 Oct; 115(46):13731-9. PMID: 21988473
We report atomically detailed molecular dynamics simulations characterizing the interaction of the RAP74 winged helix domain with the intrinsically disordered C-terminal of FCP1. The RAP74-FCP1 complex promotes the essential dephosphorylation...
5.
Wostenberg C, Quarles K, Showalter S
Biochemistry . 2010 Nov; 49(50):10728-36. PMID: 21073201
MicroRNAs (miRNAs) affect gene regulation by base pairing with mRNA and contribute to the control of cellular homeostasis. The first step in miRNA maturation is conducted in the nucleus by...
6.
Wostenberg C, Noid W, Showalter S
Biophys J . 2010 Jul; 99(1):248-56. PMID: 20655853
Over the past decade, microRNAs (miRNAs) have been shown to affect gene regulation by basepairing with messenger RNA, and their misregulation has been directly linked with cancer. DGCR8, a protein...