Scot J Matkovich
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Explore the profile of Scot J Matkovich including associated specialties, affiliations and a list of published articles.
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76
Citations
3154
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Recent Articles
1.
Matsiukevich D, Kovacs A, Li T, Kokkonen-Simon K, Matkovich S, Oladipupo S, et al.
Am J Physiol Heart Circ Physiol
. 2023 May;
325(2):H203-H231.
PMID: 37204871
Heart failure (HF) is a leading cause of morbidity and mortality particularly in older adults and patients with multiple metabolic comorbidities. Heart failure with preserved ejection fraction (HFpEF) is a...
2.
Jiang W, Adamo L, Lim K, Matkovich S, Evans S, Rocha-Resende C, et al.
PLoS One
. 2023 Mar;
18(3):e0282921.
PMID: 36996254
Necrotic and dying cells release damage-associated molecular patterns (DAMPs) that can initiate sterile inflammatory responses in the heart. Although macrophages are essential for myocardial repair and regeneration, the effect of...
3.
Verdino P, Lee S, Cooper F, Cottle S, Grealish P, Hu C, et al.
Br J Pharmacol
. 2023 Feb;
180(15):1965-1980.
PMID: 36780899
Background And Purpose: Chronic heart failure, a progressive disease with limited treatment options currently available, especially in heart failure with preserved ejection fraction (HFpEF), represents an unmet medical need as...
4.
Mathyer M, Brettmann E, Schmidt A, Goodwin Z, Oh I, Quiggle A, et al.
Nat Commun
. 2021 May;
12(1):2557.
PMID: 33963188
The genetic modules that contribute to human evolution are poorly understood. Here we investigate positive selection in the Epidermal Differentiation Complex locus for skin barrier adaptation in diverse HapMap human...
5.
Hwang H, Sandeep N, Nair R, Hu D, Zhao M, Lan I, et al.
J Am Heart Assoc
. 2021 Feb;
10(4):e017835.
PMID: 33522250
Background In complex congenital heart disease patients such as those with tetralogy of Fallot, the right ventricle (RV) is subject to pressure overload, leading to RV hypertrophy and eventually RV...
6.
McClenaghan C, Huang Y, Matkovich S, Kovacs A, Weinheimer C, Perez R, et al.
Function (Oxf)
. 2020 Sep;
1(1):zqaa004.
PMID: 32865539
Dramatic cardiomegaly arising from gain-of-function (GoF) mutations in the ATP-sensitive potassium (K) channels genes, and , is a characteristic feature of Cantú syndrome (CS). How potassium channel over-activity results in...
7.
Coste Pradas J, Auguste G, Matkovich S, Lombardi R, Chen S, Garnett T, et al.
J Am Heart Assoc
. 2020 Aug;
9(16):e015690.
PMID: 32805188
Background Mutations in the gene, encoding LMNA (lamin A/C), causes distinct disorders, including dilated cardiomyopathies, collectively referred to as laminopathies. The genes (coding and noncoding) and regulatory pathways controlled by...
8.
BET bromodomain inhibition attenuates cardiac phenotype in myocyte-specific lamin A/C-deficient mice
Auguste G, Rouhi L, Matkovich S, Coarfa C, Robertson M, Czernuszewicz G, et al.
J Clin Invest
. 2020 Jun;
130(9):4740-4758.
PMID: 32484798
Mutation in the LMNA gene, encoding lamin A/C, causes a diverse group of diseases called laminopathies. Cardiac involvement is the major cause of death and manifests as dilated cardiomyopathy, heart...
9.
Javaheri A, Bajpai G, Picataggi A, Mani S, Foroughi L, Evie H, et al.
JCI Insight
. 2019 Nov;
4(21).
PMID: 31672943
Lysosomes are at the epicenter of cellular processes critical for inflammasome activation in macrophages. Inflammasome activation and IL-1β secretion are implicated in myocardial infarction (MI) and resultant heart failure; however,...
10.
Rocha-Resende C, Weinheimer C, Bajpai G, Adamo L, Matkovich S, Schilling J, et al.
JCI Insight
. 2019 Jun;
5.
PMID: 31162139
Whereas prior studies have demonstrated an important immunomodulatory role for the neuronal cholinergic system in the heart, the role of the non-neuronal cholinergic system is not well understood. To address...