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» Authors » Savitha Deshmukh

Savitha Deshmukh

Explore the profile of Savitha Deshmukh including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 11
Citations 135
Followers 0
Related Specialties
Cell Biology
Microbiology
General Medicine
Top 10 Co-Authors
Amey Mukim
Nadejda Beliakova-Bethell
Celsa A Spina
Rachana Mishra
Sunjay Kaushal
Sudhish Sharma
Shalesh Kaushal
Mary K Lewinski
David Simpson
Xinlian Zhang
Published In
J Virol
Circulation
Virology
Front Cell Infect Microbiol
Cell Stress Chaperones
Affiliations
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Recent Articles
1.
Single-cell RNA sequencing reveals common and unique gene expression profiles in primary CD4+ T cells latently infected with HIV under different conditions
Zhang X, Qazi A, Deshmukh S, Lobato Ventura R, Mukim A, Beliakova-Bethell N
Front Cell Infect Microbiol . 2023 Dec; 13:1286168. PMID: 38156317
Background: The latent HIV reservoir represents the major barrier to a cure. One curative strategy is targeting diseased cells for elimination based on biomarkers that uniquely define these cells. Single-cell...
2.
HIV Infection Elicits Differential Transcriptomic Remodeling in CD4+ T Cells with Variable Proliferative Responses to the T Cell Receptor Stimulus
Zhang X, Deshmukh S, Mukim A, Zhang J, Beliakova-Bethell N
Pathogens . 2023 Apr; 12(4). PMID: 37111397
Identification of a cellular biomarker of latent HIV infection will facilitate the latent reservoir detection, quantification, and targeting for elimination. Unfortunately, the latency biomarkers reported in the literature define only...
3.
A Camptothetin Analog, Topotecan, Promotes HIV Latency via Interference with HIV Transcription and RNA Splicing
Mukim A, Smith D, Deshmukh S, Qazi A, Beliakova-Bethell N
J Virol . 2023 Jan; 97(2):e0163022. PMID: 36719238
Low level HIV transcription during modern antiretroviral therapy (ART) in persons with HIV is linked to residual inflammation and associated diseases, like cardiovascular disease and cancer. The "block and lock"...
4.
HIV-1 latency is established preferentially in minimally activated and non-dividing cells during productive infection of primary CD4 T cells
Soto P, Terry V, Lewinski M, Deshmukh S, Beliakova-Bethell N, Spina C
PLoS One . 2022 Jul; 17(7):e0271674. PMID: 35895672
Latently infected CD4 T cells form a stable reservoir of HIV that leads to life-long viral persistence; the mechanisms involved in establishment of this latency are not well understood. Three...
5.
Integrated proteomics and transcriptomics analyses identify novel cell surface markers of HIV latency
Beliakova-Bethell N, Manousopoulou A, Deshmukh S, Mukim A, Richman D, Garbis S, et al.
Virology . 2022 Jun; 573:50-58. PMID: 35714458
Elimination of the latent HIV cell reservoir may be possible, if the molecular identity of latently infected cells were fully elucidated. We conducted comprehensive molecular profiling, at the protein and...
6.
Use of GapmeRs for gene expression knockdowns in human primary resting CD4+ T cells
Abewe H, Deshmukh S, Mukim A, Beliakova-Bethell N
J Immunol Methods . 2019 Oct; 476:112674. PMID: 31629740
Human primary resting CD4+ T cells are difficult to transfect while preserving viability. The present study evaluated gymnotic delivery and RNase H1-dependent gene expression knockdown mediated by antisense oligonucleotides, called...
7.
Histone deacetylase inhibitors induce complex host responses that contribute to differential potencies of these compounds in HIV reactivation
Beliakova-Bethell N, Mukim A, White C, Deshmukh S, Abewe H, Richman D, et al.
J Biol Chem . 2019 Feb; 294(14):5576-5589. PMID: 30745362
Histone deacetylase (HDAC) inhibitors (HDACis) have been widely tested in clinical trials for their ability to reverse HIV latency but have yielded only limited success. One HDACi, suberoylanilide hydroxamic acid...
8.
Pharmacologic Inhibition of Nedd8 Activation Enzyme Exposes CD4-Induced Epitopes within Env on Cells Expressing HIV-1
Tokarev A, Stoneham C, Lewinski M, Mukim A, Deshmukh S, Vollbrecht T, et al.
J Virol . 2015 Dec; 90(5):2486-502. PMID: 26676780
Unlabelled: HIV-1 Vpu decreases the exposure of epitopes within the viral envelope glycoprotein (Env) on the surface of infected cells by downregulating both BST2 and CD4. To test the hypothesis...
9.
Cardiosphere-derived cells from pediatric end-stage heart failure patients have enhanced functional activity due to the heat shock response regulating the secretome
Sharma S, Mishra R, Simpson D, Wehman B, Colletti E, Deshmukh S, et al.
Stem Cells . 2015 Mar; 33(4):1213-29. PMID: 25752510
We have demonstrated that human neonatal cardiosphere-derived cells (CDCs) derived from the young are more regenerative due to their robust secretome. However, it is unclear how the decompensated pediatric heart...
10.
Celastrol, an oral heat shock activator, ameliorates multiple animal disease models of cell death
Sharma S, Mishra R, Walker B, Deshmukh S, Zampino M, Patel J, et al.
Cell Stress Chaperones . 2014 Oct; 20(1):185-201. PMID: 25300203
Protein homeostatic regulators have been shown to ameliorate single, loss-of-function protein diseases but not to treat broader animal disease models that may involve cell death. Diseases often trigger protein homeostatic...