Satish Sagar
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Explore the profile of Satish Sagar including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
145
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Recent Articles
1.
Aguilar E, Sagar S, Murray B, Rajesh C, Lei E, Michaud S, et al.
Mol Cancer Ther
. 2024 Feb;
23(6):836-853.
PMID: 38394685
Mucin-16 (MUC16) is a target for antibody-mediated immunotherapy in pancreatic ductal adenocarcinoma (PDAC) among other malignancies. The MUC16-specific monoclonal antibody AR9.6 has shown promise for PDAC immunotherapy and imaging. Here,...
2.
Rajesh C, Sagar S, Rathinavel A, Chemparathy D, Peng X, Yeh J, et al.
Int J Mol Sci
. 2022 May;
23(10).
PMID: 35628269
Elevated levels of Mucin-16 (MUC16) in conjunction with a high expression of truncated O-glycans is implicated in playing crucial roles in the malignancy of pancreatic ductal adenocarcinoma (PDAC). However, the...
3.
Struble L, Smith A, Lutz W, Grubbs G, Sagar S, Bayles K, et al.
Protein Sci
. 2022 Apr;
31(5):e4300.
PMID: 35481636
The COVID-19 pandemic caused by SARS-CoV-2 infection has led to socio-economic shutdowns and the loss of over 5 million lives worldwide. There is a need for the identification of therapeutic...
4.
Napoleon J, Sagar S, Kubica S, Boghean L, Kour S, King H, et al.
Proc Natl Acad Sci U S A
. 2022 Apr;
119(18):e2115071119.
PMID: 35476515
Activation of inhibitor of nuclear factor NF-κB kinase subunit-β (IKKβ), characterized by phosphorylation of activation loop serine residues 177 and 181, has been implicated in the early onset of cancer....
5.
Sagar S, Singh S, Mallareddy J, Sonawane Y, Napoleon J, Rana S, et al.
Eur J Med Chem
. 2021 Jun;
222:113579.
PMID: 34098465
Genetic models validated Inhibitor of nuclear factor (NF) kappa B kinase beta (IKKβ) as a therapeutic target for KRAS mutation associated pancreatic cancer. Phosphorylation of the activation loop serine residues...
6.
Sagar S, Rathinavel A, Lutz W, Struble L, Khurana S, Schnaubelt A, et al.
Clin Transl Med
. 2021 Feb;
11(2):e281.
PMID: 33635001
No abstract available.
7.
Sagar S, Leiphrakpam P, Thomas D, McAndrews K, Caffrey T, Swanson B, et al.
Cancer Lett
. 2021 Jan;
503:91-102.
PMID: 33485947
Pancreatic ductal adenocarcinoma (PDAC) is highly lethal. MUC4 (mucin4) is a heavily glycosylated protein aberrantly expressed in PDAC and promotes tumorigenesis via an unknown mechanism. To assess this, we genetically...
8.
Thomas D, Sagar S, Liu X, Lee H, Grunkemeyer J, Grandgenett P, et al.
Mol Ther
. 2020 Dec;
29(4):1557-1571.
PMID: 33359791
Aberrant expression of CA125/MUC16 is associated with pancreatic ductal adenocarcinoma (PDAC) progression and metastasis. However, knowledge of the contribution of MUC16 to pancreatic tumorigenesis is limited. Here, we show that...
9.
Sagar S, Rathinavel A, Lutz W, Struble L, Khurana S, Schnaubelt A, et al.
bioRxiv
. 2020 Sep;
PMID: 32995771
Highlights: Bromelain inhibits / cleaves the expression of ACE-2 and TMPRSS2Bromelain cleaves / degrades SARS-CoV-2 spike proteinBromelain inhibits S-Ectodomain binding and SARS-CoV-2 infection.
10.
Thomas D, Sagar S, Caffrey T, Grandgenett P, Radhakrishnan P
J Cell Mol Med
. 2019 Aug;
23(10):6885-6896.
PMID: 31389667
Aberrant expression of Sialyl-Tn (STn) antigen correlates with poor prognosis and reduced patient survival. We demonstrated that expression of Tn and STn in pancreatic ductal adenocarcinoma (PDAC) is due to...