Sascha E Liberti
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Explore the profile of Sascha E Liberti including associated specialties, affiliations and a list of published articles.
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7
Citations
115
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Recent Articles
1.
Lujan S, Garbacz M, Liberti S, Burkholder A, Kunkel T
Nucleic Acids Res
. 2024 Jul;
52(16):9574-9585.
PMID: 39016170
The endonuclease activity of Pms1 directs mismatch repair by generating a nick in the newly replicated DNA strand. Inactivating Pms2, the human homologue of yeast Pms1, increases the chances of...
2.
Jorgensen S, Liberti S, Larsen N, Lisby M, Mankouri H, Hickson I
Nucleic Acids Res
. 2019 Mar;
47(9):4597-4611.
PMID: 30838410
Telomeric regions of the genome are inherently difficult-to-replicate due to their propensity to generate DNA secondary structures and form nucleoprotein complexes that can impede DNA replication fork progression. Precisely how...
3.
Liu D, Frederiksen J, Liberti S, Lutzen A, Keijzers G, Pena-Diaz J, et al.
Nucleic Acids Res
. 2017 Sep;
45(16):9427-9440.
PMID: 28934474
DNA mismatch repair (MMR) is a highly-conserved DNA repair mechanism, whose primary role is to remove DNA replication errors preventing them from manifesting as mutations, thereby increasing the overall genome...
4.
Larsen N, Liberti S, Vogel I, Jorgensen S, Hickson I, Mankouri H
Proc Natl Acad Sci U S A
. 2017 Aug;
114(36):9665-9670.
PMID: 28827358
Proliferating cells acquire genome alterations during the act of DNA replication. This leads to mutation accumulation and somatic cell mosaicism in multicellular organisms, and is also implicated as an underlying...
5.
St Charles J, Liberti S, Williams J, Lujan S, Kunkel T
DNA Repair (Amst)
. 2015 May;
31:41-51.
PMID: 25996407
Mismatches generated during eukaryotic nuclear DNA replication are removed by two evolutionarily conserved error correction mechanisms acting in series, proofreading and mismatch repair (MMR). Defects in both processes are associated...
6.
Liberti S, Larrea A, Kunkel T
DNA Repair (Amst)
. 2012 Dec;
12(2):92-6.
PMID: 23245696
The Saccharomyces cerevisiae EXO1 gene encodes a 5' exonuclease that participates in mismatch repair (MMR) of DNA replication errors. Deleting EXO1 was previously shown to increase mutation rates to a...
7.
Liberti S, Andersen S, Wang J, May A, Miron S, Perderiset M, et al.
DNA Repair (Amst)
. 2010 Oct;
10(1):73-86.
PMID: 20970388
Human exonuclease 1 (hEXO1) is implicated in DNA metabolism, including replication, recombination and repair, substantiated by its interactions with PCNA, DNA helicases BLM and WRN, and several DNA mismatch repair...