Hocine W Mankouri
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Explore the profile of Hocine W Mankouri including associated specialties, affiliations and a list of published articles.
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19
Citations
973
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Recent Articles
1.
The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells
Brannvoll A, Xue X, Kwon Y, Kompocholi S, Simonsen A, Viswalingam K, et al.
Cell Rep
. 2020 Jul;
32(1):107849.
PMID: 32640219
Replication-blocking DNA lesions are particularly toxic to proliferating cells because they can lead to chromosome mis-segregation if not repaired prior to mitosis. In this study, we report that ZGRF1 null...
2.
Jorgensen S, Liberti S, Larsen N, Lisby M, Mankouri H, Hickson I
Nucleic Acids Res
. 2019 Mar;
47(9):4597-4611.
PMID: 30838410
Telomeric regions of the genome are inherently difficult-to-replicate due to their propensity to generate DNA secondary structures and form nucleoprotein complexes that can impede DNA replication fork progression. Precisely how...
3.
Larsen N, Hickson I, Mankouri H
Methods Mol Biol
. 2017 Oct;
1672:295-309.
PMID: 29043631
Site-specific arrest of DNA replication is a useful tool for analyzing cellular responses to DNA replication perturbation. The E. coli Tus-Ter replication barrier can be reconstituted in eukaryotic cells as...
4.
Larsen N, Liberti S, Vogel I, Jorgensen S, Hickson I, Mankouri H
Proc Natl Acad Sci U S A
. 2017 Aug;
114(36):9665-9670.
PMID: 28827358
Proliferating cells acquire genome alterations during the act of DNA replication. This leads to mutation accumulation and somatic cell mosaicism in multicellular organisms, and is also implicated as an underlying...
5.
Minocherhomji S, Ying S, Bjerregaard V, Bursomanno S, Aleliunaite A, Wu W, et al.
Nature
. 2015 Dec;
528(7581):286-90.
PMID: 26633632
Oncogene-induced DNA replication stress has been implicated as a driver of tumorigenesis. Many chromosomal rearrangements characteristic of human cancers originate from specific regions of the genome called common fragile sites...
6.
Larsen N, Hickson I, Mankouri H
Cell Cycle
. 2014 Dec;
13(19):2994-8.
PMID: 25486560
The high-affinity binding of the Tus protein to specific 21-bp sequences, called Ter, causes site-specific, and polar, DNA replication fork arrest in E coli. The Tus-Ter complex serves to coordinate...
7.
Larsen N, Sass E, Suski C, Mankouri H, Hickson I
Nat Commun
. 2014 Apr;
5:3574.
PMID: 24705096
Replication fork (RF) pausing occurs at both 'programmed' sites and non-physiological barriers (for example, DNA adducts). Programmed RF pausing is required for site-specific DNA replication termination in Escherichia coli, and...
8.
Mankouri H, Huttner D, Hickson I
EMBO J
. 2013 Sep;
32(20):2661-71.
PMID: 24065128
The eukaryotic cell cycle is conventionally viewed as comprising several discrete steps, each of which must be completed before the next one is initiated. However, emerging evidence suggests that incompletely...
9.
Ying S, Minocherhomji S, Chan K, Palmai-Pallag T, Chu W, Wass T, et al.
Nat Cell Biol
. 2013 Jul;
15(8):1001-7.
PMID: 23811685
Fragile sites are chromosomal loci with a propensity to form gaps or breaks during early mitosis, and their instability is implicated as being causative in certain neurological disorders and cancers....
10.
Mankouri H, Chu W, Hickson I
Mol Cell
. 2012 Jan;
45(1):6-7.
PMID: 22244326
In this issue, Moldovan et al. (2012) report the identification of PARI, a putative human ortholog of the yeast Srs2 protein, which potentially regulates homologous recombination repair via its ability...