Nicolai B Larsen
Overview
Explore the profile of Nicolai B Larsen including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
13
Citations
438
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Fabian Z, Kakulidis E, Hendriks I, Kuhbacher U, Larsen N, Oliva-Santiago M, et al.
Nat Commun
. 2024 Aug;
15(1):6641.
PMID: 39103378
DNA-protein crosslinks (DPCs) are toxic lesions that inhibit DNA related processes. Post-translational modifications (PTMs), including SUMOylation and ubiquitylation, play a central role in DPC resolution, but whether other PTMs are...
2.
Krakovka S, Ranjbarian F, Lujan L, Saura A, Larsen N, Jimenez-Gonzalez A, et al.
J Biol Chem
. 2022 May;
298(6):102028.
PMID: 35568200
Giardiasis is a diarrheal disease caused by the unicellular parasite Giardia intestinalis, for which metronidazole is the main treatment option. The parasite is dependent on exogenous deoxyribonucleosides for DNA replication...
3.
Liu J, Kuhbacher U, Larsen N, Borgermann N, Garvanska D, Hendriks I, et al.
EMBO J
. 2021 Aug;
40(18):e107413.
PMID: 34346517
DNA-protein crosslinks (DPCs) obstruct essential DNA transactions, posing a serious threat to genome stability and functionality. DPCs are proteolytically processed in a ubiquitin- and DNA replication-dependent manner by SPRTN and...
4.
Gallina I, Hendriks I, Hoffmann S, Larsen N, Johansen J, Colding-Christensen C, et al.
Mol Cell
. 2020 Dec;
81(3):442-458.e9.
PMID: 33321094
Lesions on DNA uncouple DNA synthesis from the replisome, generating stretches of unreplicated single-stranded DNA (ssDNA) behind the replication fork. These ssDNA gaps need to be filled in to complete...
5.
Jorgensen S, Liberti S, Larsen N, Lisby M, Mankouri H, Hickson I
Nucleic Acids Res
. 2019 Mar;
47(9):4597-4611.
PMID: 30838410
Telomeric regions of the genome are inherently difficult-to-replicate due to their propensity to generate DNA secondary structures and form nucleoprotein complexes that can impede DNA replication fork progression. Precisely how...
6.
Kose H, Larsen N, Duxin J, Yardimci H
Cell Rep
. 2019 Feb;
26(8):2113-2125.e6.
PMID: 30784593
Progression of DNA replication depends on the ability of the replisome complex to overcome nucleoprotein barriers. During eukaryotic replication, the CMG helicase translocates along the leading-strand template and unwinds the...
7.
Sparks J, Chistol G, Gao A, Raschle M, Larsen N, Mann M, et al.
Cell
. 2019 Jan;
176(1-2):167-181.e21.
PMID: 30595447
Covalent DNA-protein cross-links (DPCs) impede replication fork progression and threaten genome integrity. Using Xenopus egg extracts, we previously showed that replication fork collision with DPCs causes their proteolysis, followed by...
8.
Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts
Larsen N, Gao A, Sparks J, Gallina I, Wu R, Mann M, et al.
Mol Cell
. 2019 Jan;
73(3):574-588.e7.
PMID: 30595436
DNA-protein crosslinks (DPCs) are bulky lesions that interfere with DNA metabolism and therefore threaten genomic integrity. Recent studies implicate the metalloprotease SPRTN in S phase removal of DPCs, but how...
9.
Larsen N, Hickson I, Mankouri H
Methods Mol Biol
. 2017 Oct;
1672:295-309.
PMID: 29043631
Site-specific arrest of DNA replication is a useful tool for analyzing cellular responses to DNA replication perturbation. The E. coli Tus-Ter replication barrier can be reconstituted in eukaryotic cells as...
10.
Larsen N, Liberti S, Vogel I, Jorgensen S, Hickson I, Mankouri H
Proc Natl Acad Sci U S A
. 2017 Aug;
114(36):9665-9670.
PMID: 28827358
Proliferating cells acquire genome alterations during the act of DNA replication. This leads to mutation accumulation and somatic cell mosaicism in multicellular organisms, and is also implicated as an underlying...