Sasanka Ramanadham
Overview
Explore the profile of Sasanka Ramanadham including associated specialties, affiliations and a list of published articles.
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Articles
60
Citations
4157
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Recent Articles
1.
White T, Almutairi A, Gai-Tusing Y, Stephenson D, Stephenson B, Chalfant C, et al.
Front Immunol
. 2024 Oct;
15():1444639.
PMID: 39359722
Introduction: We reported that Ca-independent phospholipase Aβ (iPLAβ)-derived lipids (iDLs) contribute to type 1 diabetes (T1D) onset. As CD4 and CD8 T cells are critical in promoting β-cell death, we...
2.
Almutairi A, White T, Stephenson D, Stephenson B, Gai-Tusing Y, Goel P, et al.
Diabetes
. 2024 Sep;
73(12):2022-2033.
PMID: 39283670
Article Highlights:
3.
Hawkins C, Jones A, Gordon E, Harsh Y, Ziebro J, Willey C, et al.
Cell Death Discov
. 2023 Dec;
9(1):451.
PMID: 38086808
Sphingolipid metabolism is dysregulated in many cancers, allowing cells to evade apoptosis through increased sphingosine-1-phosphate (S1P) and decreased ceramides. Ceramidases hydrolyze ceramides to sphingosine, which is phosphorylated by sphingosine kinases...
4.
Vallejo M, Sarkar S, Elliott E, Henry H, Powell S, Diaz Ludovico I, et al.
Sci Data
. 2023 Nov;
10(1):837.
PMID: 38017024
Extracellular vesicles play major roles in cell-to-cell communication and are excellent biomarker candidates. However, studying plasma extracellular vesicles is challenging due to contaminants. Here, we performed a proteomics meta-analysis of...
5.
Diaz Ludovico I, Sarkar S, Elliott E, Virtanen S, Erlund I, Ramanadham S, et al.
Expert Opin Ther Targets
. 2023 Sep;
27(9):793-806.
PMID: 37706269
Introduction: Type 1 diabetes (T1D) is an autoimmune disease in which pro-inflammatory and cytotoxic signaling drive the death of the insulin-producing β cells. This complex signaling is regulated in part...
6.
Alsharif H, Latimer M, Perez K, Alexander J, Rahman M, Challa A, et al.
Metabolites
. 2023 Jun;
13(6).
PMID: 37367869
Effective energy expenditure is critical for maintaining body weight (BW). However, underlying mechanisms contributing to increased BW remain unknown. We characterized the role of brain angiogenesis inhibitor-3 (BAI3/ADGRB3), an adhesion...
7.
Ramanadham S, Turk J, Bhatnagar S
Compr Physiol
. 2023 Jun;
13(3):5023-5049.
PMID: 37358504
Impaired glucose tolerance (IGT) and β-cell dysfunction in insulin resistance associated with obesity lead to type 2 diabetes (T2D). Glucose-stimulated insulin secretion (GSIS) from β-cells occurs via a canonical pathway...
8.
Aguirre R, Kulkarni A, Becker M, Lei X, Sarkar S, Ramanadham S, et al.
Mol Metab
. 2022 Jul;
63:101545.
PMID: 35817393
Background: Type 1 diabetes (T1D) is a complex autoimmune disorder whose pathogenesis involves an intricate interplay between β cells of the pancreatic islet, other islet cells, and cells of the...
9.
Hawkins C, Jones A, Gordon E, Williford S, Harsh Y, Ziebro J, et al.
Cells
. 2022 Jun;
11(12).
PMID: 35741006
Glioblastoma (GBM) remains one of the most aggressive cancers, partially due to its ability to migrate into the surrounding brain. The sphingolipid balance, or the balance between ceramides and sphingosine-1-phosphate,...
10.
Xu G, Chen J, Jo S, Grayson T, Ramanadham S, Koizumi A, et al.
Endocrinology
. 2022 Mar;
163(5).
PMID: 35290443
Endoplasmic reticulum (ER) stress contributes to pancreatic beta-cell apoptosis in diabetes, but the factors involved are still not fully elucidated. Growth differentiation factor 15 (GDF15) is a stress response gene...