Sarina Meinen
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Explore the profile of Sarina Meinen including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Reinhard J, Lin S, McKee K, Meinen S, Crosson S, Sury M, et al.
Sci Transl Med
. 2017 Jun;
9(396).
PMID: 28659438
-related muscular dystrophy ( MD or MDC1A) is the most frequent form of early-onset, fatal congenital muscular dystrophies. It is caused by mutations in , the gene encoding laminin-α2, the...
2.
Willmann R, Gordish-Dressman H, Meinen S, Ruegg M, Yu Q, Nagaraju K, et al.
J Neuromuscul Dis
. 2017 May;
4(2):115-126.
PMID: 28550268
Laminin-α2 related Congenital Muscular Dystrophy (LAMA2-CMD) is a progressive muscle disease caused by partial or complete deficiency of laminin-211, a skeletal muscle extracellular matrix protein. In the last decade, basic...
3.
McKee K, Crosson S, Meinen S, Reinhard J, Ruegg M, Yurchenco P
J Clin Invest
. 2017 Feb;
127(3):1075-1089.
PMID: 28218617
Mutations in laminin α2-subunit (Lmα2, encoded by LAMA2) are linked to approximately 30% of congenital muscular dystrophy cases. Mice with a homozygous mutation in Lama2 (dy2J mice) express a nonpolymerizing...
4.
Meinen S, Lin S, Ruegg M, Punga A
PLoS One
. 2012 Sep;
7(8):e44148.
PMID: 22952904
Myasthenia Gravis (MG) patients suffer from chronic fatigue of skeletal muscles, even after initiation of proper immunosuppressive medication. Since the localization of neuronal nitric oxide synthase (nNOS) at the muscle...
5.
Meinen S, Lin S, Ruegg M
Skelet Muscle
. 2012 Sep;
2(1):18.
PMID: 22943509
Background: Laminin-α2-deficient congenital muscular dystrophy (MDC1A) is a severe muscle-wasting disease for which no curative treatment is available. Antagonists of the angiotensin II receptor type 1 (AT1), including the anti-hypertensive...
6.
Meinen S, Lin S, Thurnherr R, Erb M, Meier T, Ruegg M
EMBO Mol Med
. 2011 Jun;
3(8):465-79.
PMID: 21674808
Mutations in LAMA2 cause a severe form of congenital muscular dystrophy, called MDC1A. Studies in mouse models have shown that transgenic expression of a designed, miniaturized form of the extracellular...
7.
Punga A, Lin S, Oliveri F, Meinen S, Ruegg M
Exp Neurol
. 2011 May;
230(2):207-17.
PMID: 21565192
MuSK antibody seropositive (MuSK+) Myasthenia Gravis (MG) patients present a distinct selective fatigue, and sometimes atrophy, of bulbar, facial and neck muscles. Here, we study the mechanism underlying the focal...
8.
Punga A, Maj M, Lin S, Meinen S, Ruegg M
Eur J Neurosci
. 2011 Jan;
33(5):890-8.
PMID: 21255125
Muscle-specific tyrosine kinase (MuSK) is involved in the formation and maintenance of the neuromuscular junction (NMJ), and is necessary for NMJ integrity. As muscle involvement is strikingly selective in pathological...
9.
Erb M, Meinen S, Barzaghi P, Sumanovski L, Courdier-Fruh I, Ruegg M, et al.
J Pharmacol Exp Ther
. 2009 Sep;
331(3):787-95.
PMID: 19759319
Laminin alpha2-deficient congenital muscular dystrophy, called MDC1A, is a rare, devastating genetic disease characterized by severe neonatal hypotonia ("floppy infant syndrome"), peripheral neuropathy, inability to stand or walk, respiratory distress,...
10.
Meinen S, Barzaghi P, Lin S, Lochmuller H, Ruegg M
J Cell Biol
. 2007 Mar;
176(7):979-93.
PMID: 17389231
Mutations in laminin-alpha2 cause a severe congenital muscular dystrophy, called MDC1A. The two main receptors that interact with laminin-alpha2 are dystroglycan and alpha7beta1 integrin. We have previously shown in mouse...