Myelin-associated Glycoprotein Inhibits Neurite Outgrowth Through Inactivation of the Small GTPase Rap1

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 2020 Jan 28

PMID 31985825

Citations 1

Authors

Elena Nikulina

Vasiliki Gkioka

Mustafa M Siddiq

Wilfredo Mellado

Melissa Hilaire

Christine R Cain

Sari S Hannila

Marie T Filbin

Affiliations

Soon will be listed here.

Abstract

Rap1 is a small GTPase that has been implicated in dendritic development and plasticity. In this study, we investigated the role of Rap1 in axonal growth and its activation in response to neurotrophins and myelin-associated inhibitors. We report that Rap1 is activated by brain-derived neurotrophic factor and that this activation can be blocked by myelin-associated glycoprotein (MAG) or central nervous system myelin, which also induced increases in Rap1GAP1 levels. In addition, we demonstrate that adenoviral overexpression of Rap1 enhances neurite outgrowth in the presence of MAG and myelin, while inhibition of Rap1 activity through overexpression of Rap1GAP1 blocks neurite outgrowth. These findings suggest that Rap1GAP1 negatively regulates neurite outgrowth, making it a potential therapeutic target to promote axonal regeneration.

Citing Articles

1,800 MHz Radiofrequency Electromagnetic Irradiation Impairs Neurite Outgrowth With a Decrease in Rap1-GTP in Primary Mouse Hippocampal Neurons and Neuro2a Cells.

Li Y, Deng P, Chen C, Ma Q, Pi H, He M Front Public Health. 2021; 9:771508.

PMID: 34881219 PMC: 8646047. DOI: 10.3389/fpubh.2021.771508.

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