Sara Barozzi
Overview
Explore the profile of Sara Barozzi including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
971
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0
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Recent Articles
1.
Nespolo A, Stefenatti L, Pellarin I, Gambelli A, Rampioni Vinciguerra G, Karimbayli J, et al.
Sci Adv
. 2024 Nov;
10(46):eadp6567.
PMID: 39536107
PARP inhibitors (PARPi) represent a game-changing treatment for patients with ovarian cancer with tumors deficient for the homologous recombination (HR) pathway treated with platinum (Pt)-based therapy. PARPi exert their cytotoxic...
2.
Popeda M, Kowalski K, Wenta T, Beznoussenko G, Rychlowski M, Mironov A, et al.
Exp Mol Med
. 2024 Sep;
56(9):2016-2032.
PMID: 39218980
Micronuclei (MN) can form through many mechanisms, including the breakage of aberrant cytokinetic chromatin bridges. The frequent observation of MN in tumors suggests that they might not merely be passive...
3.
Curti L, Rohban S, Bianchi N, Croci O, Andronache A, Barozzi S, et al.
Nat Commun
. 2024 Aug;
15(1):7100.
PMID: 39155303
The identification of genes involved in replicative stress is key to understanding cancer evolution and to identify therapeutic targets. Here, we show that CDK12 prevents transcription-replication conflicts (TRCs) and the...
4.
Bastianello G, Porcella G, Beznoussenko G, Kidiyoor G, Ascione F, Li Q, et al.
Cell Rep
. 2023 Dec;
42(12):113555.
PMID: 38088930
Ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) DNA damage response (DDR) kinases contain elastic domains. ATM also responds to reactive oxygen species (ROS) and ATR to nuclear...
5.
Hershey B, Barozzi S, Orsenigo F, Pompei S, Iannelli F, Kamrad S, et al.
Sci Adv
. 2023 Sep;
9(37):eadh4184.
PMID: 37713487
Cancers feature substantial intratumoral heterogeneity of genetic and phenotypically distinct lineages. Although interactions between coexisting lineages are emerging as a potential contributor to tumor evolution, the extent and nature of...
6.
Gioia U, Tavella S, Martinez-Orellana P, Cicio G, Colliva A, Ceccon M, et al.
Nat Cell Biol
. 2023 Mar;
25(4):550-564.
PMID: 36894671
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the RNA virus responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 was reported to alter several cellular pathways, its impact...
7.
Gritti I, Basso V, Rinchai D, Corigliano F, Pivetti S, Gaviraghi M, et al.
EMBO J
. 2022 Oct;
41(22):e108040.
PMID: 36215697
The ribonuclease DIS3 is one of the most frequently mutated genes in the hematological cancer multiple myeloma, yet the basis of its tumor suppressor function in this disease remains unclear....
8.
Kidiyoor G, Li Q, Bastianello G, Bruhn C, Giovannetti I, Mohamood A, et al.
Nat Commun
. 2020 Sep;
11(1):4828.
PMID: 32973141
ATR responds to mechanical stress at the nuclear envelope and mediates envelope-associated repair of aberrant topological DNA states. By combining microscopy, electron microscopic analysis, biophysical and in vivo models, we...
9.
Giovarelli M, Zecchini S, Martini E, Garre M, Barozzi S, Ripolone M, et al.
Cell Death Differ
. 2020 Feb;
27(8):2383-2401.
PMID: 32042098
Mitochondria change distribution across cells following a variety of pathophysiological stimuli. The mechanisms presiding over this redistribution are yet undefined. In a murine model overexpressing Drp1 specifically in skeletal muscle,...
10.
Pessina F, Giavazzi F, Yin Y, Gioia U, Vitelli V, Galbiati A, et al.
Nat Cell Biol
. 2019 Oct;
21(10):1286-1299.
PMID: 31570834
Damage-induced long non-coding RNAs (dilncRNA) synthesized at DNA double-strand breaks (DSBs) by RNA polymerase II are necessary for DNA-damage-response (DDR) focus formation. We demonstrate that induction of DSBs results in...