Dario Parazzoli
Overview
Explore the profile of Dario Parazzoli including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
987
Followers
0
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Recent Articles
1.
Martin S, Scorzoni S, Cordone S, Mazzagatti A, Beznoussenko G, Gunn A, et al.
Science
. 2024 Aug;
385(6712):eadj7446.
PMID: 39208097
Chromosomal instability (CIN) generates micronuclei-aberrant extranuclear structures that catalyze the acquisition of complex chromosomal rearrangements present in cancer. Micronuclei are characterized by persistent DNA damage and catastrophic nuclear envelope collapse,...
2.
Curti L, Rohban S, Bianchi N, Croci O, Andronache A, Barozzi S, et al.
Nat Commun
. 2024 Aug;
15(1):7100.
PMID: 39155303
The identification of genes involved in replicative stress is key to understanding cancer evolution and to identify therapeutic targets. Here, we show that CDK12 prevents transcription-replication conflicts (TRCs) and the...
3.
Bastianello G, Kidiyoor G, Lowndes C, Li Q, Bonnal R, Godwin J, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(29):e2404551121.
PMID: 38990945
Confined cell migration hampers genome integrity and activates the ATR and ATM mechano-transduction pathways. We investigated whether the mechanical stress generated by metastatic interstitial migration contributes to the enhanced chromosomal...
4.
Rosso I, Jones-Weinert C, Rossiello F, Cabrini M, Brambillasca S, Munoz-Sagredo L, et al.
Nat Commun
. 2023 Nov;
14(1):7086.
PMID: 37925537
Alternative lengthening of telomeres (ALT) is a telomere maintenance mechanism activated in ~10-15% of cancers, characterized by telomeric damage. Telomeric damage-induced long non-coding RNAs (dilncRNAs) are transcribed at dysfunctional telomeres...
5.
Hershey B, Barozzi S, Orsenigo F, Pompei S, Iannelli F, Kamrad S, et al.
Sci Adv
. 2023 Sep;
9(37):eadh4184.
PMID: 37713487
Cancers feature substantial intratumoral heterogeneity of genetic and phenotypically distinct lineages. Although interactions between coexisting lineages are emerging as a potential contributor to tumor evolution, the extent and nature of...
6.
Varinelli L, Guaglio M, Brich S, Zanutto S, Belfiore A, Zanardi F, et al.
J Mol Cell Biol
. 2022 Dec;
14(11).
PMID: 36460033
Peritoneal metastases (PM) from colorectal cancer (CRC) are associated with poor survival. The extracellular matrix (ECM) plays a fundamental role in modulating the homing of CRC metastases to the peritoneum....
7.
Green B, Marazzini M, Hershey B, Fardin A, Li Q, Wang Z, et al.
Small
. 2022 Dec;
18(48):e2206567.
PMID: 36453561
No abstract available.
8.
Gritti I, Basso V, Rinchai D, Corigliano F, Pivetti S, Gaviraghi M, et al.
EMBO J
. 2022 Oct;
41(22):e108040.
PMID: 36215697
The ribonuclease DIS3 is one of the most frequently mutated genes in the hematological cancer multiple myeloma, yet the basis of its tumor suppressor function in this disease remains unclear....
9.
Palamidessi A, Malinverno C, Frittoli E, Corallino S, Barbieri E, Sigismund S, et al.
Nat Mater
. 2022 Sep;
21(12):1448.
PMID: 36167801
No abstract available.
10.
Green B, Marazzini M, Hershey B, Fardin A, Li Q, Wang Z, et al.
Small
. 2022 Mar;
18(17):e2106097.
PMID: 35344274
Circulating tumor cell (CTC) clusters are associated with increased metastatic potential and worse patient prognosis, but are rare, difficult to count, and poorly characterized biophysically. The PillarX device described here...