Sandra Merscher
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Explore the profile of Sandra Merscher including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Ahmad A, Shi J, Ansari S, Merscher S, Pollack A, Zeidan Y, et al.
Radiother Oncol
. 2023 Jul;
187:109813.
PMID: 37468066
Background: Radiation nephropathy (RN) can be a severe late complication for patients treated with radiotherapy (RT) targeting abdominal and paraspinal tumors. Recent studies investigating the mechanisms of RT-mediated injury in...
12.
Ito M, Ducasa G, Molina J, Varona Santos J, Mallela S, Kim J, et al.
Sci Rep
. 2023 Jun;
13(1):9616.
PMID: 37316538
Decreased ATP Binding Cassette Transporter A1 (ABCA1) expression and caspase-4-mediated noncanonical inflammasome contribution have been described in podocytes in diabetic kidney disease (DKD). To investigate a link between these pathways,...
13.
Ge M, Molina J, Kim J, Mallela S, Ahmad A, Varona Santos J, et al.
Elife
. 2023 May;
12.
PMID: 37129368
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are anti-hyperglycemic agents that prevent glucose reabsorption in proximal tubular cells. SGLT2i improves renal outcomes in both diabetic and non-diabetic patients, indicating it may have beneficial...
14.
Drexler Y, Molina J, Elfassy T, Ma R, Christoffersen C, Kurano M, et al.
Kidney Int Rep
. 2023 Apr;
8(4):884-897.
PMID: 37069998
Introduction: Dysregulation of sphingolipid and cholesterol metabolism contributes to the pathogenesis of glomerular diseases (GDs). Apolipoprotein M (ApoM) promotes cholesterol efflux and modulates the bioactive sphingolipid sphingosine-1-phosphate (S1P). Glomerular ApoM...
15.
Gurumani M, Mallela S, Varona J, Merscher S, Fornoni A, Al-Ali H
Methods Mol Biol
. 2023 Jan;
2625:163-174.
PMID: 36653642
Lipid droplets (LDs), initially thought to be mere lipid storage structures, are highly dynamic organelles with complex functions that control cell fate and behavior. In recent years, their relevance as...
16.
Mitrofanova A, Fontanella A, Burke G, Merscher S, Fornoni A
Cells
. 2022 Nov;
11(22).
PMID: 36429063
Diabetes is the leading cause of chronic kidney disease worldwide. Despite the burden, the factors contributing to the development and progression of diabetic kidney disease (DKD) remain to be fully...
17.
Daehn I, Merscher S
Front Med (Lausanne)
. 2022 Oct;
9:1026202.
PMID: 36313992
No abstract available.
18.
Mitrofanova A, Fontanella A, Tolerico M, Mallela S, Molina David J, Zuo Y, et al.
J Am Soc Nephrol
. 2022 Oct;
33(12):2153-2173.
PMID: 36198430
Background: The signaling molecule stimulator of IFN genes (STING) was identified as a crucial regulator of the DNA-sensing cyclic GMP-AMP synthase (cGAS)-STING pathway, and this signaling pathway regulates inflammation and...
19.
Mallela S, Merscher S, Fornoni A
Int J Mol Sci
. 2022 Apr;
23(8).
PMID: 35457062
Sphingolipids, which act as a bioactive signaling molecules, are involved in several cellular processes such as cell survival, proliferation, migration and apoptosis. An imbalance in the levels of sphingolipids can...
20.
Ito M, Gurumani M, Merscher S, Fornoni A
Biomolecules
. 2022 Mar;
12(3).
PMID: 35327540
Mitochondrial dysfunction plays an important role in the pathogenesis and progression of diabetic kidney disease (DKD). In this review, we will discuss mitochondrial dysfunction observed in preclinical models of DKD...