Sandra L Siedlak
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Explore the profile of Sandra L Siedlak including associated specialties, affiliations and a list of published articles.
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91
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3547
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Recent Articles
1.
Wang W, Zhao F, Torres S, Harris P, Wang X, Peng L, et al.
J Alzheimers Dis
. 2024 Jul;
100(s1):S327-S339.
PMID: 39058444
Background: Space radiation was linked to neurological damage and behavioral deficits which raised concerns of increased degenerative risk on the brain and development of Alzheimer's disease following space travel. Objective:...
2.
Gao J, Okolo O, Siedlak S, Friedland R, Wang X
J Neuropathol Exp Neurol
. 2024 Jul;
83(11):917-926.
PMID: 39001793
Iron deposition is a hallmark of amyotrophic lateral sclerosis (ALS) and has been strongly implicated in its pathogenesis. As a byproduct of cellular oxidative stress, iron dysregulation modifies basal levels...
3.
Wang W, Zhao F, Lu Y, Siedlak S, Fujioka H, Feng H, et al.
Acta Neuropathol Commun
. 2023 Apr;
11(1):54.
PMID: 37004141
Loss of synapses is the most robust pathological correlate of Alzheimer's disease (AD)-associated cognitive deficits, although the underlying mechanism remains incompletely understood. Synaptic terminals have abundant mitochondria which play an...
4.
Shao C, Zhu J, Ma X, Siedlak S, Cohen M, Lerner A, et al.
Free Radic Biol Med
. 2022 Feb;
182:23-33.
PMID: 35182730
Mitochondrial membrane protein-associated with neurodegeneration (MPAN) is a rare genetic disease characterized by aggressive neurodegeneration and massive iron accumulation in patients' brains. Genetics studies identified defects in C19orf12 locus being...
5.
Zhao F, Xu Y, Gao S, Qin L, Austria Q, Siedlak S, et al.
Mol Neurodegener
. 2021 Oct;
16(1):70.
PMID: 34593014
Background: N6-methyladenosine (mA) modification of RNA influences fundamental aspects of RNA metabolism and mA dysregulation is implicated in various human diseases. In this study, we explored the potential role of...
6.
Wang C, Shao C, Zhang L, Siedlak S, Meabon J, Peskind E, et al.
Antioxidants (Basel)
. 2021 Jul;
10(6).
PMID: 34203583
Traumatic brain injury caused by blast is associated with long-term neuropathological changes including tau phosphorylation and pathology. In this study, we aimed to determine changes in initial tau phosphorylation after...
7.
Niu M, Zhao F, Bondelid K, Siedlak S, Torres S, Fujioka H, et al.
Aging Cell
. 2021 Mar;
20(5):e13347.
PMID: 33745227
D620N mutation in the vacuolar protein sorting 35 ortholog (VPS35) gene causes late-onset, autosomal dominant familial Parkinson's disease (PD) and contributes to idiopathic PD. However, how D620N mutation leads to...
8.
Han S, Nandy P, Austria Q, Siedlak S, Torres S, Fujioka H, et al.
Cells
. 2020 Jan;
9(1).
PMID: 31947766
It is believed that mitochondrial fragmentation cause mitochondrial dysfunction and neuronal deficits in Alzheimer's disease. We recently reported that constitutive knockout of the mitochondria fusion protein mitofusin2 (Mfn2) in the...
9.
Zhao F, Siedlak S, Torres S, Xu Q, Tang B, Zhu X
Mol Neurobiol
. 2018 Dec;
56(7):5157-5166.
PMID: 30519817
The canonical Wnt pathway is critical for both the development and adulthood survival and homeostatic maintenance of the midbrain dopaminergic (DA) neurons. Expanding evidence has demonstrated that genetic factors associated...
10.
Wang C, Zhao F, Shen K, Wang W, Siedlak S, Lee H, et al.
Brain Pathol
. 2018 Dec;
29(4):530-543.
PMID: 30515907
Disturbed neuronal cholesterol homeostasis has been observed in Alzheimer disease (AD) and contributes to the pathogenesis of AD. As the master switch of cholesterol biosynthesis, the sterol regulatory element-binding protein...