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Sandip B Bharate

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Articles 146
Citations 1367
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Recent Articles
1.
Veeram A, Patekar R, Bharate S, Andugulapati S, Sistla R
Phytother Res . 2025 Feb; PMID: 40007210
Inflammatory cardiomyopathy is an inflammatory condition characterised by infiltrating inflammatory cells into the heart, which causes impaired myocardial function. Sinigrin (SNG) has been reported to possess antioxidant and anti-inflammatory properties....
2.
Reddy C, Eedara A, Malik S, Mondhe D, Bharate S, Andugulapati S
Bioorg Chem . 2025 Feb; 157:108262. PMID: 39946986
The non-selective toxicity of colchicine remains a major barrier to its development as an anticancer agent. Here, we report a colchicine derivative, 8l, which exhibits potent and selective antiproliferative activity...
3.
Sharma A, Jain S, Jha P, Rudrawar S, Bharate S, Jadhav H
ACS Infect Dis . 2025 Jan; 11(2):493-505. PMID: 39804666
Antimicrobial drug resistance is a significant global health challenge, causing hundreds of thousands of deaths annually and severely impacting healthcare systems worldwide. Several reported antimicrobial compounds have a guanidine motif,...
4.
Sharma A, Rudrawar S, Bharate S, Jadhav H
RSC Med Chem . 2025 Jan; 16(2):652-693. PMID: 39790124
Alzheimer's disease (AD) is a complex, incurable neurological condition characterized by cognitive decline, cholinergic neuron reduction, and neuronal loss. Its exact pathology remains uncertain, but multiple treatment hypotheses have emerged....
5.
Somarowthu T, Patekar R, Bharate S
Bioorg Chem . 2025 Jan; 155():108111. PMID: 39787913
Cyclin-dependent kinases, CDK7 and CDK9 play critical roles in cancer by regulating transcriptional processes essential for cell proliferation and survival. Their dysregulation leads to aberrant gene expression, promoting oncogenic pathways...
6.
Wadje B, Somarowthu T, Thakur S, Jadhav H, Bharate S
J Biomol Struct Dyn . 2024 Dec; :1-16. PMID: 39660560
The phosphoinositide kinase, PIKfyve is a lipid kinase that plays a vital role in membrane trafficking, endosomal transport, retroviral budding, and toll-like receptor signaling. Thus, it has emerged as a...
7.
Sharma A, Nayak M, Thakur S, Jadhav H, Bharate S
ChemMedChem . 2024 Dec; :e202400685. PMID: 39644140
Alzheimer's disease (AD) is a complex neurodegenerative disorder having limited treatment options. The beta-site APP cleaving enzyme 1 (BACE-1) is a key target for therapeutic intervention in Alzheimer's disease. To...
8.
Bharate S, Lindsley C
J Med Chem . 2024 Dec; 67(23):20723-20730. PMID: 39629819
No abstract available.
9.
Choudhary S, Kumar V, Sharma K, Gour A, Sahrawat A, Jotshi A, et al.
ACS Pharmacol Transl Sci . 2024 Oct; 7(10):3017-3033. PMID: 39416964
Aging is usually accompanied by mitochondrial dysfunction, reduced energy levels, and cell death in the brain and other tissues. Mitochondria play a crucial role in maintaining cellular energy through oxidative...
10.
Sharma A, Rudrawar S, Sharma A, Bharate S, Jadhav H
RSC Adv . 2024 Aug; 14(37):26703-26722. PMID: 39184009
Alzheimer's disease (AD) manifests as a progressive decline in cognitive function and mental behavior. Targeting two crucial enzymes associated with AD, acetylcholinesterase (AChE) and BACE 1 (Beta-site APP Cleaving Enzyme),...