Samuele Gherardi
Overview
Explore the profile of Samuele Gherardi including associated specialties, affiliations and a list of published articles.
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20
Citations
688
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Recent Articles
1.
Teinturier R, Ziki R, Kassem L, Luo Y, Malbeteau L, Gherardi S, et al.
Breast Cancer Res Treat
. 2021 Sep;
190(3):389-401.
PMID: 34561764
Purpose: Menin, encoded by the MEN1 gene, was recently reported to be involved in breast cancers, though the underlying mechanisms remain elusive. In the current study, we sought to further...
2.
Teinturier R, Luo Y, Decaussin-Petrucci M, Vlaeminck-Guillem V, Vacherot F, Firlej V, et al.
Oncogene
. 2020 Dec;
40(6):1118-1127.
PMID: 33323967
Dysregulated androgen receptor (AR) plays a crucial role in prostate cancer (PCa) development, though further factors involved in its regulation remain to be identified. Recently, paradoxical results were reported on...
3.
Gherardi S, Bovolenta M, Passarelli C, Falzarano M, Pigini P, Scotton C, et al.
Biochim Biophys Acta Gene Regul Mech
. 2017 Sep;
1860(11):1138-1147.
PMID: 28867298
The dystrophin gene (DMD) is the largest gene in the human genome, mapping on the Xp21 chromosome locus. It spans 2.2Mb and accounts for approximately 0,1% of the entire human...
4.
Gherardi S, Ripoche D, Mikaelian I, Chanal M, Teinturier R, Goehrig D, et al.
Biochim Biophys Acta Gene Regul Mech
. 2017 Feb;
1860(4):427-437.
PMID: 28215965
Although Men1 is a well-known tumour suppressor gene, little is known about the functions of Menin, the protein it encodes for. Since few years, numerous publications support a major role...
5.
Bonnavion R, Teinturier R, Gherardi S, Leteurtre E, Yu R, Cordier-Bussat M, et al.
J Pathol
. 2017 Feb;
242(1):90-101.
PMID: 28188614
Foxa2, known as one of the pioneer factors, plays a crucial role in islet development and endocrine functions. Its expression and biological functions are regulated by various factors, including, in...
6.
Xue C, Yu D, Gherardi S, Koach J, Milazzo G, Gamble L, et al.
Oncotarget
. 2016 Jul;
7(34):54937-54951.
PMID: 27448979
Amplification of the MYCN oncogene, a member of the MYC family of transcriptional regulators, is one of the most powerful prognostic markers identified for poor outcome in neuroblastoma, the most...
7.
Sun Y, Bell J, Carter D, Gherardi S, Poulos R, Milazzo G, et al.
Cancer Res
. 2015 Oct;
75(23):5143-54.
PMID: 26471359
MYCN gene amplification in neuroblastoma drives a gene expression program that correlates strongly with aggressive disease. Mechanistically, trimethylation of histone H3 lysine 4 (H3K4) at target gene promoters is a...
8.
Lau D, Flemming C, Gherardi S, Perini G, Oberthuer A, Fischer M, et al.
Oncotarget
. 2015 Apr;
6(17):15510-23.
PMID: 25860940
MYCN amplification occurs in 20% of neuroblastomas and is strongly related to poor clinical outcome. We have identified folate-mediated one-carbon metabolism as highly upregulated in neuroblastoma tumors with MYCN amplification...
9.
Evans L, Chen L, Milazzo G, Gherardi S, Perini G, Willmore E, et al.
Cancer Lett
. 2015 Apr;
363(1):37-45.
PMID: 25843293
SKP2 is the substrate recognition subunit of the ubiquitin ligase complex which targets p27(KIP1) for degradation. Induced at the G1/S transit of the cell cycle, SKP2 is frequently overexpressed in...
10.
Gherardi S, Valli E, Erriquez D, Perini G
Front Oncol
. 2013 Mar;
3:42.
PMID: 23482921
Neuroblastoma is the most common extra cranial solid tumor in childhood and the most frequently diagnosed neoplasm during the infancy. MYCN amplification and overexpression occur in about 25% of total...