Stephen Tang
Overview
Explore the profile of Stephen Tang including associated specialties, affiliations and a list of published articles.
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25
Citations
371
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Recent Articles
1.
Ho L, Ramanujan S, Pramod N, Tang S, Bena J, De S
Urology
. 2024 Aug;
194:231-237.
PMID: 39181508
Objective: To compare post-operative outcomes in patients who underwent holmium laser enucleation of the prostate (HoLEP) for benign prostatic hyperplasia (BPH) and had urodynamic evidence of bladder hypocontractility versus those...
2.
Tang S, Conte V, Zhang D, Zedaveinyte R, Lampe G, Wiegand T, et al.
Science
. 2024 Aug;
386(6717):eadq0876.
PMID: 39116258
Defense-associated reverse transcriptase (DRT) systems perform DNA synthesis to protect bacteria against viral infection, but the identities and functions of their DNA products remain largely unknown. We show that DRT2...
3.
Zedaveinyte R, Meers C, Le H, Mortman E, Tang S, Lampe G, et al.
Science
. 2024 Jul;
385(6705):eadm8189.
PMID: 38991068
TnpB nucleases represent the evolutionary precursors to CRISPR-Cas12 and are widespread in all domains of life. IS605-family TnpB homologs function as programmable RNA-guided homing endonucleases in bacteria, driving transposon maintenance...
4.
Wiegand T, Hoffmann F, Walker M, Tang S, Richard E, Le H, et al.
Nature
. 2024 Jun;
631(8020):439-448.
PMID: 38926585
Transposon-encoded tnpB and iscB genes encode RNA-guided DNA nucleases that promote their own selfish spread through targeted DNA cleavage and homologous recombination. These widespread gene families were repeatedly domesticated over...
5.
Tang S, Conte V, Zhang D, Zedaveinyte R, Lampe G, Wiegand T, et al.
bioRxiv
. 2024 May;
PMID: 38766058
Bacteria defend themselves from viral infection using diverse immune systems, many of which sense and target foreign nucleic acids. Defense-associated reverse transcriptase (DRT) systems provide an intriguing counterpoint to this...
6.
Rogava M, Aprati T, Chi W, Melms J, Hug C, Davis S, et al.
Nat Cancer
. 2024 Jan;
5(3):433-447.
PMID: 38286827
Liver metastasis (LM) confers poor survival and therapy resistance across cancer types, but the mechanisms of liver-metastatic organotropism remain unknown. Here, through in vivo CRISPR-Cas9 screens, we found that Pip4k2c...
7.
Emergence of RNA-guided transcription factors via domestication of transposon-encoded TnpB nucleases
Wiegand T, Hoffmann F, Walker M, Tang S, Richard E, Le H, et al.
bioRxiv
. 2023 Dec;
PMID: 38076855
Transposon-encoded genes encode RNA-guided DNA nucleases that promote their own selfish spread through targeted DNA cleavage and homologous recombination. This widespread gene family was repeatedly domesticated over evolutionary timescales, leading...
8.
Zedaveinyte R, Meers C, Le H, Mortman E, Tang S, Lampe G, et al.
bioRxiv
. 2023 Dec;
PMID: 38045383
TnpB nucleases represent the evolutionary precursors to CRISPR-Cas12 and are widespread in all domains of life, presumably due to the critical roles they play in transposon proliferation. IS605family TnpB homologs...
9.
Tang S, Sternberg S
Science
. 2023 Oct;
382(6669):370-371.
PMID: 37883564
RNA-guided DNA writing enzymes offer promise for programmable gene insertion.
10.
Meers C, Le H, Pesari S, Hoffmann F, Walker M, Gezelle J, et al.
Nature
. 2023 Sep;
622(7984):863-871.
PMID: 37758954
Insertion sequences are compact and pervasive transposable elements found in bacteria, which encode only the genes necessary for their mobilization and maintenance. IS200- and IS605-family transposons undergo 'peel-and-paste' transposition catalysed...