Tyler S Halpin-Healy
Overview
Explore the profile of Tyler S Halpin-Healy including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
350
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Recent Articles
1.
Lampe G, King R, Halpin-Healy T, Klompe S, Hogan M, Vo P, et al.
bioRxiv
. 2023 Mar;
PMID: 36993517
Traditional genome-editing reagents such as CRISPR-Cas9 achieve targeted DNA modification by introducing double-strand breaks (DSBs), thereby stimulating localized DNA repair by endogenous cellular repair factors. While highly effective at generating...
2.
Lampe G, King R, Halpin-Healy T, Klompe S, Hogan M, Vo P, et al.
Nat Biotechnol
. 2023 Mar;
42(1):87-98.
PMID: 36991112
Conventional genome engineering with CRISPR-Cas9 creates double-strand breaks (DSBs) that lead to undesirable byproducts and reduce product purity. Here we report an approach for programmable integration of large DNA sequences...
3.
Halpin-Healy T, Klompe S, Sternberg S, Fernandez I
Nature
. 2020 Aug;
585(7825):E12.
PMID: 32843756
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
4.
Halpin-Healy T, Klompe S, Sternberg S, Fernandez I
Nature
. 2019 Dec;
577(7789):271-274.
PMID: 31853065
Bacteria use adaptive immune systems encoded by CRISPR and Cas genes to maintain genomic integrity when challenged by pathogens and mobile genetic elements. Type I CRISPR-Cas systems typically target foreign...
5.
Klompe S, Vo P, Halpin-Healy T, Sternberg S
Nature
. 2019 Jun;
571(7764):219-225.
PMID: 31189177
Conventional CRISPR-Cas systems maintain genomic integrity by leveraging guide RNAs for the nuclease-dependent degradation of mobile genetic elements, including plasmids and viruses. Here we describe a notable inversion of this...