Matt W G Walker
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Explore the profile of Matt W G Walker including associated specialties, affiliations and a list of published articles.
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9
Citations
43
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Recent Articles
1.
Tang S, Conte V, Zhang D, Zedaveinyte R, Lampe G, Wiegand T, et al.
Science
. 2024 Aug;
386(6717):eadq0876.
PMID: 39116258
Defense-associated reverse transcriptase (DRT) systems perform DNA synthesis to protect bacteria against viral infection, but the identities and functions of their DNA products remain largely unknown. We show that DRT2...
2.
Wiegand T, Hoffmann F, Walker M, Tang S, Richard E, Le H, et al.
Nature
. 2024 Jun;
631(8020):439-448.
PMID: 38926585
Transposon-encoded tnpB and iscB genes encode RNA-guided DNA nucleases that promote their own selfish spread through targeted DNA cleavage and homologous recombination. These widespread gene families were repeatedly domesticated over...
3.
Tang S, Conte V, Zhang D, Zedaveinyte R, Lampe G, Wiegand T, et al.
bioRxiv
. 2024 May;
PMID: 38766058
Bacteria defend themselves from viral infection using diverse immune systems, many of which sense and target foreign nucleic acids. Defense-associated reverse transcriptase (DRT) systems provide an intriguing counterpoint to this...
4.
Emergence of RNA-guided transcription factors via domestication of transposon-encoded TnpB nucleases
Wiegand T, Hoffmann F, Walker M, Tang S, Richard E, Le H, et al.
bioRxiv
. 2023 Dec;
PMID: 38076855
Transposon-encoded genes encode RNA-guided DNA nucleases that promote their own selfish spread through targeted DNA cleavage and homologous recombination. This widespread gene family was repeatedly domesticated over evolutionary timescales, leading...
5.
Meers C, Le H, Pesari S, Hoffmann F, Walker M, Gezelle J, et al.
Nature
. 2023 Sep;
622(7984):863-871.
PMID: 37758954
Insertion sequences are compact and pervasive transposable elements found in bacteria, which encode only the genes necessary for their mobilization and maintenance. IS200- and IS605-family transposons undergo 'peel-and-paste' transposition catalysed...
6.
Walker M, Klompe S, Zhang D, Sternberg S
Nucleic Acids Res
. 2023 Apr;
51(9):4519-4535.
PMID: 37078593
CRISPR-associated transposases (CASTs) direct DNA integration downstream of target sites using the RNA-guided DNA binding activity of nuclease-deficient CRISPR-Cas systems. Transposition relies on several key protein-protein and protein-DNA interactions, but...
7.
Meers C, Le H, Pesari S, Hoffmann F, Walker M, Gezelle J, et al.
bioRxiv
. 2023 Mar;
PMID: 36993599
Insertion sequences (IS) are compact and pervasive transposable elements found in bacteria, which encode only the genes necessary for their mobilization and maintenance. IS /IS elements undergo 'peel-and-paste' transposition catalyzed...
8.
Walker M, Klompe S, Zhang D, Sternberg S
bioRxiv
. 2023 Jan;
PMID: 36711804
CRISPR-associated transposons (CASTs) direct DNA integration downstream of target sites using the RNA-guided DNA binding activity of nuclease-deficient CRISPR-Cas systems. Transposition relies on several key protein-protein and protein-DNA interactions, but...
9.
Deonarine A, Walker M, Westerheide S
Cell Stress Chaperones
. 2021 Jan;
26(2):417-431.
PMID: 33392968
The transcription factor heat shock factor-1 (HSF-1) regulates the heat shock response (HSR), a cytoprotective response induced by proteotoxic stresses. Data from model organisms has shown that HSF-1 also has...