Samuel C Griffiths
Overview
Explore the profile of Samuel C Griffiths including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
207
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0
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Recent Articles
1.
Malinauskas T, Moore G, Rudolf A, Eggington H, Belnoue-Davis H, El Omari K, et al.
Nat Commun
. 2024 Jun;
15(1):4976.
PMID: 38862520
Twisted gastrulation (TWSG1) is an evolutionarily conserved secreted glycoprotein which controls signaling by Bone Morphogenetic Proteins (BMPs). TWSG1 binds BMPs and their antagonist Chordin to control BMP signaling during embryonic...
2.
Griffiths S, Tan J, Wagner A, Blazer L, Adams J, Srinivasan S, et al.
Elife
. 2024 May;
13.
PMID: 38780011
The receptor tyrosine kinase ROR2 mediates noncanonical WNT5A signaling to orchestrate tissue morphogenetic processes, and dysfunction of the pathway causes Robinow syndrome, brachydactyly B, and metastatic diseases. The domain(s) and...
3.
Liu J, Chiang H, Xiong W, Laurent V, Griffiths S, Dulfer J, et al.
J Immunother Cancer
. 2023 Jun;
11(6).
PMID: 37328286
Background: Immune exclusion (IE) where tumors deter the infiltration of immune cells into the tumor microenvironment has emerged as a key mechanism underlying immunotherapy resistance. We recently reported a novel...
4.
Clark L, Atkin K, Whelan F, Brentnall A, Harris G, Towell A, et al.
J Biol Chem
. 2023 Jan;
299(3):102936.
PMID: 36702253
Staphylococcus aureus and Staphylococcus epidermidis are frequently associated with medical device infections that involve establishment of a bacterial biofilm on the device surface. Staphylococcal surface proteins Aap, SasG, and Pls...
5.
Griffiths S, Schwab R, El Omari K, Bishop B, Iverson E, Malinauskas T, et al.
Nat Commun
. 2021 Dec;
12(1):7171.
PMID: 34887403
Hedgehog (HH) morphogen signalling, crucial for cell growth and tissue patterning in animals, is initiated by the binding of dually lipidated HH ligands to cell surface receptors. Hedgehog-Interacting Protein (HHIP),...
6.
Whelan F, Lafita A, Gilburt J, Degut C, Griffiths S, Jenkins H, et al.
Proc Natl Acad Sci U S A
. 2021 Jun;
118(23).
PMID: 34074781
Changes at the cell surface enable bacteria to survive in dynamic environments, such as diverse niches of the human host. Here, we reveal "Periscope Proteins" as a widespread mechanism of...
7.
Robinson R, Griffiths S, van de Haar L, Malinauskas T, van Battum E, Zelina P, et al.
Cell
. 2021 Mar;
184(8):2103-2120.e31.
PMID: 33740419
During cell migration or differentiation, cell surface receptors are simultaneously exposed to different ligands. However, it is often unclear how these extracellular signals are integrated. Neogenin (NEO1) acts as an...
8.
Whelan F, Lafita A, Griffiths S, Cooper R, Whittingham J, Turkenburg J, et al.
Proc Natl Acad Sci U S A
. 2019 Dec;
116(52):26540-26548.
PMID: 31818940
groups A and B cause serious infections, including early onset sepsis and meningitis in newborns. Rib domain-containing surface proteins are found associated with invasive strains and elicit protective immunity in...
9.
Elegheert J, Behiels E, Bishop B, Scott S, Woolley R, Griffiths S, et al.
Nat Protoc
. 2018 Nov;
13(12):2991-3017.
PMID: 30455477
Structural, biochemical and biophysical studies of eukaryotic soluble and membrane proteins require their production in milligram quantities. Although large-scale protein expression strategies based on transient or stable transfection of mammalian...
10.
Nolan R, Alvarez L, Griffiths S, Elegheert J, Siebold C, Padilla-Parra S
J Vis Exp
. 2018 Aug;
(137).
PMID: 30080195
Number and brightness is a calibration-free fluorescence fluctuation spectroscopy (FFS) technique for detecting protein homo-oligomerization. It can be employed using a conventional confocal microscope equipped with digital detectors. A protocol...