Christian Siebold
Overview
Explore the profile of Christian Siebold including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
89
Citations
4076
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Malinauskas T, Moore G, Rudolf A, Eggington H, Belnoue-Davis H, El Omari K, et al.
Nat Commun
. 2024 Jun;
15(1):4976.
PMID: 38862520
Twisted gastrulation (TWSG1) is an evolutionarily conserved secreted glycoprotein which controls signaling by Bone Morphogenetic Proteins (BMPs). TWSG1 binds BMPs and their antagonist Chordin to control BMP signaling during embryonic...
2.
Griffiths S, Tan J, Wagner A, Blazer L, Adams J, Srinivasan S, et al.
Elife
. 2024 May;
13.
PMID: 38780011
The receptor tyrosine kinase ROR2 mediates noncanonical WNT5A signaling to orchestrate tissue morphogenetic processes, and dysfunction of the pathway causes Robinow syndrome, brachydactyly B, and metastatic diseases. The domain(s) and...
3.
Ansell T, Healy M, Coupland C, Sansom M, Siebold C
Structure
. 2024 Apr;
32(7):1011-1022.e3.
PMID: 38636523
Membrane-bound O-acyltransferases (MBOATs) are membrane-embedded enzymes that catalyze acyl chain transfer to a diverse group of substrates, including lipids, small molecules, and proteins. MBOATs share a conserved structural core, despite...
4.
Bakhshalizadeh S, Afkhami F, Bell K, Robevska G, van den Bergen J, Cronin S, et al.
Mol Cell Endocrinol
. 2024 Mar;
587:112212.
PMID: 38521400
Research Question: Premature ovarian insufficiency (POI) is characterised by amenorrhea associated with elevated follicle stimulating hormone (FSH) under the age of 40 years and affects 1-3.7% women. Genetic factors explain...
5.
Lanyon-Hogg T, Ritzefeld M, Zhang L, Andrei S, Pogranyi B, Mondal M, et al.
Angew Chem Weinheim Bergstr Ger
. 2024 Mar;
133(24):13654-13659.
PMID: 38504937
The mammalian membrane-bound -acyltransferase (MBOAT) superfamily is involved in biological processes including growth, development and appetite sensing. MBOATs are attractive drug targets in cancer and obesity; however, information on the...
6.
Ritzefeld M, Zhang L, Xiao Z, Andrei S, Boyd O, Masumoto N, et al.
J Med Chem
. 2024 Jan;
67(2):1061-1078.
PMID: 38198226
Hedgehog signaling is involved in embryonic development and cancer growth. Functional activity of secreted Hedgehog signaling proteins is dependent on -terminal palmitoylation, making the palmitoyl transferase Hedgehog acyltransferase (HHAT), a...
7.
Ansell T, Song W, Coupland C, Carrique L, Corey R, Duncan A, et al.
Nat Commun
. 2023 Nov;
14(1):7774.
PMID: 38012131
Cryo-electron microscopy (cryo-EM) enables the determination of membrane protein structures in native-like environments. Characterising how membrane proteins interact with the surrounding membrane lipid environment is assisted by resolution of lipid-like...
8.
Ansell T, Corey R, Viti L, Kinnebrew M, Rohatgi R, Siebold C, et al.
Sci Adv
. 2023 Aug;
9(34):eadh1609.
PMID: 37611095
Patched1 (PTCH1) is a tumor suppressor protein of the mammalian Hedgehog (HH) signaling pathway, implicated in embryogenesis and tissue homeostasis. PTCH1 inhibits the G protein-coupled receptor Smoothened (SMO) via a...
9.
Coupland C, Ansell T, Sansom M, Siebold C
Curr Opin Struct Biol
. 2023 Apr;
80:102589.
PMID: 37040671
The membrane-bound O-acyltransferase (MBOAT) superfamily catalyses the transfer of acyl chains to substrates implicated in essential cellular functions. Aberrant function of MBOATs is associated with various diseases and MBOATs are...
10.
Siebold C, Rohatgi R
Annu Rev Biochem
. 2023 Mar;
92:273-298.
PMID: 37001135
Ligands of the Hedgehog (HH) pathway are paracrine signaling molecules that coordinate tissue development in metazoans. A remarkable feature of HH signaling is the repeated use of cholesterol in steps...