Sami Nourreddine
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Explore the profile of Sami Nourreddine including associated specialties, affiliations and a list of published articles.
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11
Citations
197
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Recent Articles
1.
Nourreddine S, Doctor Y, Dailamy A, Forget A, Lee Y, Chinn B, et al.
bioRxiv
. 2024 Nov;
PMID: 39574586
Towards comprehensively investigating the genotype-phenotype relationships governing the human pluripotent stem cell state, we generated an expressed genome-scale CRISPRi Perturbation Cell Atlas in KOLF2.1J human induced pluripotent stem cells (hiPSCs)...
2.
Dailamy A, Lyu W, Nourreddine S, Tong M, Rainaldi J, McDonald D, et al.
Nat Commun
. 2024 Nov;
15(1):9818.
PMID: 39537590
Adenosine deaminases acting on RNA (ADARs) impact diverse cellular processes and pathological conditions, but their functions in early cell-fate specification remain less understood. To gain insights here, we began by...
3.
Tong M, Palmer N, Dailamy A, Kumar A, Khaliq H, Han S, et al.
Nat Biomed Eng
. 2024 Aug;
9(1):109-126.
PMID: 39187662
Circularization can improve RNA persistence, yet simple and scalable approaches to achieve this are lacking. Here we report two methods that facilitate the pursuit of circular RNAs (cRNAs): cRNAs developed...
4.
Clark T, Mohan J, Schaffer L, Obernier K, Al Manir S, Churas C, et al.
bioRxiv
. 2024 Jun;
PMID: 38826258
This article describes the Cell Maps for Artificial Intelligence (CM4AI) project and its goals, methods, standards, current datasets, software tools , status, and future directions. CM4AI is the in the...
5.
Booth B, Nourreddine S, Katrekar D, Savva Y, Bose D, Long T, et al.
Mol Ther
. 2023 Jan;
31(6):1533-1549.
PMID: 36620962
RNA therapeutics have had a tremendous impact on medicine, recently exemplified by the rapid development and deployment of mRNA vaccines to combat the COVID-19 pandemic. In addition, RNA-targeting drugs have...
6.
Houles T, Lavoie G, Nourreddine S, Cheung W, Vaillancourt-Jean E, Guerin C, et al.
Nat Commun
. 2022 Oct;
13(1):6457.
PMID: 36309522
Melanoma is the deadliest form of skin cancer and considered intrinsically resistant to chemotherapy. Nearly all melanomas harbor mutations that activate the RAS/mitogen-activated protein kinase (MAPK) pathway, which contributes to...
7.
Vadnjal N, Nourreddine S, Lavoie G, Serres M, Roux P, Paluch E
J Cell Sci
. 2022 Jul;
135(16).
PMID: 35892282
Many animal cell shape changes are driven by gradients in the contractile tension of the actomyosin cortex, a thin cytoskeletal network supporting the plasma membrane. Elucidating cortical tension control is...
8.
Aubert L, Nandagopal N, Steinhart Z, Lavoie G, Nourreddine S, Berman J, et al.
Nat Commun
. 2020 Jul;
11(1):3701.
PMID: 32709883
Despite its importance in human cancers, including colorectal cancers (CRC), oncogenic KRAS has been extremely challenging to target therapeutically. To identify potential vulnerabilities in KRAS-mutated CRC, we characterize the impact...
9.
Nourreddine S, Lavoie G, Paradis J, Ben El Kadhi K, Meant A, Aubert L, et al.
Cell Rep
. 2020 May;
31(7):107660.
PMID: 32433969
In human cells, the expression of ∼1,000 genes is modulated throughout the cell cycle. Although some of these genes are controlled by specific transcriptional programs, very little is known about...
10.
Meant A, Gao B, Lavoie G, Nourreddine S, Jung F, Aubert L, et al.
Mol Cell Proteomics
. 2019 Nov;
19(1):50-64.
PMID: 31678930
The RAS/mitogen-activated protein kinase (MAPK) signaling pathway regulates various biological functions, including cell survival, proliferation and migration. This pathway is frequently deregulated in cancer, including melanoma, which is the most...