Samar Abdulkhalek
Overview
Explore the profile of Samar Abdulkhalek including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
425
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0
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Recent Articles
1.
Harless W, Lewis B, Qorri B, Abdulkhalek S, Szewczuk M
Cells
. 2023 May;
12(9).
PMID: 37174732
We discovered a novel therapeutic target critical for SARS-CoV-2, cellular infectivity and the induction of the cytokine release syndrome. Here, we show that the mammalian enzyme neuraminidase-1 (Neu-1) is part...
2.
Veleeparambil M, Poddar D, Abdulkhalek S, Kessler P, Yamashita M, Chattopadhyay S, et al.
J Immunol
. 2018 Mar;
200(8):2809-2818.
PMID: 29531172
Mammalian TLRs recognize microbial infection or cell death-associated danger signals and trigger the appropriate cellular response. These responses determine the strength and the outcome of the host-microbe interaction. TLRs are...
3.
Abdulkhalek S, Geen O, Brodhagen L, Haxho F, Alghamdi F, Allison S, et al.
Clin Transl Med
. 2016 Mar;
3(1):28.
PMID: 26932374
Background: Snail, a transcriptional factor and repressor of E-cadherin is well known for its role in cellular invasion. It can regulate epithelial to mesenchymal transition (EMT) during embryonic development and...
4.
Chattopadhyay S, Veleeparambil M, Poddar D, Abdulkhalek S, Bandyopadhyay S, Fensterl V, et al.
EMBO Rep
. 2015 Sep;
16(11):1535-47.
PMID: 26341626
Mammalian Toll-like receptors (TLR) recognize microbial products and elicit transient immune responses that protect the infected host from disease. TLR4--which signals from both plasma and endosomal membranes--is activated by bacterial...
5.
Hrynyk M, Ellis J, Haxho F, Allison S, Steele J, Abdulkhalek S, et al.
Drug Des Devel Ther
. 2015 Aug;
9:4573-86.
PMID: 26309402
Poly (lactic-co-glycolic acid) (PLGA) copolymers have been extensively used in cancer research. PLGA can be chemically engineered for conjugation or encapsulation of drugs in a particle formulation. We reported that...
6.
Haxho F, Allison S, Alghamdi F, Brodhagen L, Kuta V, Abdulkhalek S, et al.
Breast Cancer (Dove Med Press)
. 2014 Dec;
6:191-203.
PMID: 25525387
Background: Triple-negative breast cancers (TNBCs) lack the estrogen, progesterone, and epidermal growth factor (EGF) receptor-2 (HER2/neu) receptors. Patients with TNBC have typical high grading, more frequent relapses, and exhibit poorer...
7.
Alghamdi F, Guo M, Abdulkhalek S, Crawford N, Amith S, Szewczuk M
Cell Signal
. 2014 Mar;
26(6):1355-68.
PMID: 24583283
Insulin-induced insulin receptor (IR) tyrosine kinase activation and insulin cell survival responses have been reported to be under the regulation of a membrane associated mammalian neuraminidase-1 (Neu1). The molecular mechanism(s)...
8.
OShea L, Abdulkhalek S, Allison S, Neufeld R, Szewczuk M
Onco Targets Ther
. 2014 Jan;
7:117-34.
PMID: 24470763
Background: Resistance to drug therapy, along with high rates of metastasis, contributes to the low survival rate in patients diagnosed with pancreatic cancer. An alternate treatment for human pancreatic cancer...
9.
Gilmour A, Abdulkhalek S, Cheng T, Alghamdi F, Jayanth P, OShea L, et al.
Cell Signal
. 2013 Sep;
25(12):2587-603.
PMID: 23993964
Epidermal growth factor (EGF)-induced EGFR tyrosine kinase receptor activation in cancer cell survival responses has become a strategic molecular-targeting clinical therapeutic intent, but the failures of these targeted approaches in...
10.
Abdulkhalek S, Szewczuk M
Cell Signal
. 2013 Jul;
25(11):2093-105.
PMID: 23827939
The precise mechanism(s) by which intracellular TOLL-like receptors (TLRs) become activated by their ligands remains unclear. Here, we report a molecular organizational G-protein coupled receptor (GPCR) signaling platform to potentiate...