Samantha L Sampson
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Explore the profile of Samantha L Sampson including associated specialties, affiliations and a list of published articles.
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44
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1043
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Recent Articles
1.
Bekale R, Maphasa R, DSouza S, Hsu N, Walters A, Okugbeni N, et al.
ACS Infect Dis
. 2025 Feb;
11(3):610-625.
PMID: 39995313
Tuberculosis (TB) is the leading cause of death from infectious disease. Macrophages are the primary immune responders and become the primary host cells for the causative agent . Following the...
2.
Irabin A, Ollewagen T, Smith C, Ahmed R, Reineke J, Reijnders R, et al.
Eur J Pharm Sci
. 2025 Feb;
207:107037.
PMID: 39933629
Since the antibiotic golden era of the mid-20th century, there have been limited antibiotics approved, while antibiotic resistance continues to escalate disproportionately, outpacing the rate of novel antibiotic discovery. This...
3.
Coetzee J, Kriel N, Loubser J, Dippenaar A, Sampson S, Malherbe S, et al.
Sci Rep
. 2024 Nov;
14(1):27686.
PMID: 39532967
Current tuberculosis (TB) treatment is typically effective against drug-susceptible Mycobacterium tuberculosis, but can fail due to acquired drug resistance or phenotypic resistance. M. tuberculosis persisters, a subpopulation of viable but...
4.
Subramaniam S, Joyce P, Ogunniyi A, Dube A, Sampson S, Lehr C, et al.
ACS Infect Dis
. 2024 Jan;
10(2):337-349.
PMID: 38295053
Bacterial pathogens are constantly evolving to outsmart the host immune system and antibiotics developed to eradicate them. One key strategy involves the ability of bacteria to survive and replicate within...
5.
Kapp E, Calitz H, Streicher E, Dippenaar A, Egieyeh S, Jordaan A, et al.
Tuberculosis (Edinb)
. 2023 May;
141:102350.
PMID: 37244249
A series of molecules containing bulky lipophilic scaffolds was screened for activity against Mycobacterium tuberculosis and a number of compounds with antimycobacterial activity were identified. The most active compound, (2E)-N-(adamantan-1-yl)-3-phenylprop-2-enamide...
6.
Parbhoo T, Schurz H, Mouton J, Sampson S
Front Cell Infect Microbiol
. 2022 Dec;
12:981827.
PMID: 36530432
Introduction: As infection with Mycobacterium tuberculosis progresses, the bacilli experience various degrees of host stressors in the macrophage phagosome such as low pH, nutrient deprivation, or exposure to toxic agents,...
7.
Parbhoo T, Mouton J, Sampson S
Front Cell Infect Microbiol
. 2022 Oct;
12:956607.
PMID: 36237425
exhibits a remarkable ability to interfere with the host antimicrobial response. The pathogen exploits elaborate strategies to cope with diverse host-induced stressors by modulating its metabolism and physiological state to...
8.
Kriel N, Newton-Foot M, Bennion O, Aldridge B, Mehaffy C, Belisle J, et al.
BMC Microbiol
. 2022 May;
22(1):140.
PMID: 35590245
Background: Bacteria require specialized secretion systems for the export of molecules into the extracellular space to modify their environment and scavenge for nutrients. The ESX-3 secretion system is required by...
9.
Cloete R, Shahbaaz M, Grobbelaar M, Sampson S, Christoffels A
PLoS One
. 2021 Nov;
16(11):e0259348.
PMID: 34727137
Nicotinamide-nucleotide adenylyl transferase (Rv2421c) was selected as a potential drug target, because it has been shown, in vitro, to be essential for Mycobacterium tuberculosis growth. It is conserved between mycobacterium...
10.
Chisompola N, Streicher E, Dippenaar A, Whitfield M, Tembo M, Mwanza S, et al.
Tuberculosis (Edinb)
. 2021 Sep;
130:102122.
PMID: 34517268
Tuberculosis (TB) caused by Mycobacterium tuberculosis remains a major cause of death worldwide. Diverse genotypes have been demonstrated to drive the epidemiology of drug resistant (DR-) TB globally. Currently, there...