Nicolaas C Gey van Pittius
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Explore the profile of Nicolaas C Gey van Pittius including associated specialties, affiliations and a list of published articles.
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38
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1873
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Recent Articles
1.
Bruiners N, Schurz H, Daya M, Salie M, van Helden P, Kinnear C, et al.
Immunogenetics
. 2020 Jun;
72(5):305-314.
PMID: 32556499
Several genetic studies have implicated genes that encode for components of the innate immune response in tuberculosis (TB) susceptibility. The complement system is an early player in the innate immune...
2.
Chihota V, Niehaus A, Streicher E, Wang X, Sampson S, Mason P, et al.
PLoS One
. 2018 Aug;
13(8):e0200632.
PMID: 30067763
Objective: To investigate the distribution of Mycobacterium tuberculosis genotypes across Africa. Methods: The SITVIT2 global repository and PUBMED were searched for spoligotype and published genotype data respectively, of M. tuberculosis...
3.
Heunis T, Dippenaar A, Warren R, van Helden P, van der Merwe R, Gey van Pittius N, et al.
J Proteome Res
. 2017 Aug;
16(10):3841-3851.
PMID: 28820946
Mycobacterium tuberculosis consists of a large number of different strains that display unique virulence characteristics. Whole-genome sequencing has revealed substantial genetic diversity among clinical M. tuberculosis isolates, and elucidating the...
4.
Loots D, Swanepoel C, Newton-Foot M, Gey van Pittius N
Microb Pathog
. 2016 Oct;
100:268-275.
PMID: 27744102
The ESX-1 gene cluster, encoding the Type-VII secretion (T7S) system and its virulence associated proteins, ESAT-6 and CFP-10, is thought to be responsible for the transport of extracellular proteins across...
5.
Gcebe N, Michel A, Gey van Pittius N, Rutten V
Front Microbiol
. 2016 Jul;
7:795.
PMID: 27375559
The Esx and PE/PPE families of proteins are among the most immunodominant mycobacterial antigens and have thus been the focus of research to develop vaccines and immunological tests for diagnosis...
6.
Phelan J, Coll F, Bergval I, Anthony R, Warren R, Sampson S, et al.
BMC Genomics
. 2016 Mar;
17:151.
PMID: 26923687
Background: Approximately 10% of the Mycobacterium tuberculosis genome is made up of two families of genes that are poorly characterized due to their high GC content and highly repetitive nature....
7.
van Halsema C, Chihota V, Gey van Pittius N, Fielding K, Lewis J, van Helden P, et al.
Biomed Res Int
. 2015 Jul;
2015:959107.
PMID: 26180817
Background: The clinical relevance of nontuberculous mycobacteria (NTM), detected by liquid more than solid culture in sputum specimens from a South African mining workforce, is uncertain. We aimed to describe...
8.
Fortuin S, Tomazella G, Nagaraj N, Sampson S, Gey van Pittius N, Soares N, et al.
Front Microbiol
. 2015 Feb;
6:6.
PMID: 25713560
Reversible protein phosphorylation, regulated by protein kinases and phosphatases, mediates a switch between protein activity and cellular pathways that contribute to a large number of cellular processes. The Mycobacterium tuberculosis...
9.
Parsons S, Drewe J, Gey van Pittius N, Warren R, van Helden P
Emerg Infect Dis
. 2013 Nov;
19(12):2004-7.
PMID: 24274183
The organism that causes tuberculosis in meerkats (Suricata suricatta) has been poorly characterized. Our genetic analysis showed it to be a novel member of the Mycobacterium tuberculosis complex and closely...
10.
Muller B, Chihota V, Pillay M, Klopper M, Streicher E, Coetzee G, et al.
PLoS One
. 2013 Sep;
8(8):e70919.
PMID: 24058399
Background: South Africa shows one of the highest global burdens of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). Since 2002, MDR-TB in South Africa has been treated by a...