Sam Chen
Overview
Explore the profile of Sam Chen including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
1898
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Recent Articles
11.
Witzigmann D, Kulkarni J, Leung J, Chen S, Cullis P, van der Meel R
Adv Drug Deliv Rev
. 2020 Jul;
159:344-363.
PMID: 32622021
Hereditary genetic disorders, cancer, and infectious diseases of the liver affect millions of people around the globe and are a major public health burden. Most contemporary treatments offer limited relief...
12.
Roberts M, Barvalia M, Silva J, Cederberg R, Chu W, Wong A, et al.
Circ Res
. 2020 Mar;
126(10):e61-e79.
PMID: 32151196
Rationale: Monocytes are key effectors of the mononuclear phagocyte system, playing critical roles in regulating tissue homeostasis and coordinating inflammatory reactions, including those involved in chronic inflammatory diseases such as...
13.
Kulkarni J, Witzigmann D, Chen S, Cullis P, van der Meel R
Acc Chem Res
. 2019 Aug;
52(9):2435-2444.
PMID: 31397996
Delivering nucleic acid-based therapeutics to cells is an attractive approach to target the genetic cause of various diseases. In contrast to conventional small molecule drugs that target gene products (i.e.,...
14.
Chen S, Zaifman J, Kulkarni J, Zhigaltsev I, Tam Y, Ciufolini M, et al.
J Control Release
. 2018 Jul;
286:46-54.
PMID: 30026080
Lipid nanoparticles (LNPs) are playing a leading role in enabling clinical applications of gene therapies based on DNA or RNA polymers. One factor impeding clinical acceptance of LNP therapeutics is...
15.
Kulkarni J, Darjuan M, Mercer J, Chen S, van der Meel R, Thewalt J, et al.
ACS Nano
. 2018 Apr;
12(5):4787-4795.
PMID: 29614232
Lipid nanoparticles (LNPs) containing short interfering RNA (LNP-siRNA) and optimized ionizable cationic lipids are now clinically validated systems for silencing disease-causing genes in hepatocytes following intravenous administration. However, the mechanism...
16.
Neumann U, Ho J, Chen S, Tam Y, Cullis P, Kieffer T
Mol Metab
. 2017 Oct;
6(10):1161-1172.
PMID: 29031717
Objective: Hyperglucagonemia is present in many forms of diabetes and contributes to hyperglycemia, and glucagon suppression can ameliorate diabetes in mice. Leptin, a glucagon suppressor, can also reverse diabetes in...
17.
Kulkarni J, Tam Y, Chen S, Tam Y, Zaifman J, Cullis P, et al.
Nanoscale
. 2017 Sep;
9(36):13600-13609.
PMID: 28876010
A straightforward "bottom-up" synthesis is described for efficient entrapment of inorganic hydrophobic nanoparticles (HNPs) consisting of iron oxide, gold, or quantum dots within the hydrophobic core of lipid nanoparticles (LNPs)....
18.
Lee J, Zhang K, Tam Y, Quick J, Tam Y, Lin P, et al.
Mol Ther Nucleic Acids
. 2017 Jan;
5:e348.
PMID: 28131285
The androgen receptor plays a critical role in the progression of prostate cancer. Here, we describe targeting the prostate-specific membrane antigen using a lipid nanoparticle formulation containing small interfering RNA...
19.
Kulkarni J, Myhre J, Chen S, Tam Y, Danescu A, Richman J, et al.
Nanomedicine
. 2017 Jan;
13(4):1377-1387.
PMID: 28038954
Lipid nanoparticles (LNPs) containing distearoylphosphatidlycholine (DSPC), and ionizable amino-lipids such as dilinoleylmethyl-4-dimethylaminobutyrate (DLin-MC3-DMA) are potent siRNA delivery vehicles in vivo. Here we explore the utility of similar LNP systems as...
20.
Wang H, Tam Y, Chen S, Zaifman J, van der Meel R, Ciufolini M, et al.
Mol Ther
. 2016 Sep;
24(12):2100-2108.
PMID: 27633442
The therapeutic applications of lipid nanoparticle (LNP) formulations of small interfering RNA (siRNA), are hampered by inefficient delivery of encapsulated siRNA to the cytoplasm following endocytosis. Recent work has shown...