Sachin Chaugule
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Explore the profile of Sachin Chaugule including associated specialties, affiliations and a list of published articles.
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11
Citations
91
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Recent Articles
1.
Chaugule S, Constantinou C, John A, Micha D, Eekhoff M, Gravallese E, et al.
Hum Gene Ther
. 2025 Feb;
36(5-6):597-617.
PMID: 39932815
Osteogenesis imperfecta (OI) is a rare genetic disorder characterized by bone fragility due to reduced bone quality, often accompanied by low bone mass, recurrent fractures, hearing loss, skeletal abnormalities, and...
2.
Anwar A, Kaur T, Chaugule S, Yang Y, Mago A, Shim J, et al.
Sensors (Basel)
. 2024 Oct;
24(19).
PMID: 39409211
Osteoporosis, a prevalent ailment worldwide, compromises bone strength and resilience, particularly afflicting the elderly population. This condition significantly heightens susceptibility to fractures even from trivial incidents, such as minor falls...
3.
Sato T, Chaugule S, Greenblatt M, Gao G, Shim J
Hum Gene Ther
. 2024 Apr;
35(9-10):329-341.
PMID: 38661537
The development of bone-targeting drug delivery systems holds immense promise for improving the treatment of skeletal diseases. By precisely delivering therapeutic agents to the affected areas of bone, these strategies...
4.
Yang Y, Sato T, Chaugule S, Ma H, Xie J, Gao G, et al.
Mol Ther Nucleic Acids
. 2024 Jan;
35(1):102111.
PMID: 38261950
Osteogenesis imperfecta (OI) is a genetic disorder characterized by bone fragility, low bone mass, fractures, and extraskeletal manifestations. Since OI is commonly caused by single-nucleotide mutation(s) in the or genes...
5.
Stavre Z, Kim J, Yang Y, Nundel K, Chaugule S, Sato T, et al.
Proc Natl Acad Sci U S A
. 2023 May;
120(19):e2218019120.
PMID: 37141171
Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to systemic and articular bone loss by activating bone resorption and suppressing bone formation. Despite current therapeutic agents, inflammation-induced bone...
6.
Lin C, Yang Q, Guo D, Xie J, Yang Y, Chaugule S, et al.
Nat Commun
. 2022 Nov;
13(1):6869.
PMID: 36369293
Although skeletal progenitors provide a reservoir for bone-forming osteoblasts, the major energy source for their osteogenesis remains unclear. Here, we demonstrate a requirement for mitochondrial oxidative phosphorylation in the osteogenic...
7.
Yang Y, Kim J, Xie J, Chaugule S, Lin C, Ma H, et al.
Nat Commun
. 2022 Oct;
13(1):6175.
PMID: 36258013
Heterotopic ossification is the most disabling feature of fibrodysplasia ossificans progressiva, an ultra-rare genetic disorder for which there is currently no prevention or treatment. Most patients with this disease harbor...
8.
Kim J, Yang Y, Hong J, Chaugule S, Chun H, van der Meulen M, et al.
Elife
. 2022 Aug;
11.
PMID: 35975983
Emerging evidence supports that osteogenic differentiation of skeletal progenitors is a key determinant of overall bone formation and bone mass. Despite extensive studies showing the function of mitogen-activated protein kinases...
9.
Chaugule S, Kim J, Yang Y, Knobeloch K, He X, Shim J
Int J Mol Sci
. 2021 Oct;
22(19.
PMID: 34638628
Disturbance in a differentiation program of skeletal stem cells leads to indecorous skeletogenesis. Growing evidence suggests that a fine-tuning of ubiquitin-mediated protein degradation is crucial for skeletal stem cells to...
10.
Yang Y, Xie J, Chaugule S, Wang D, Kim J, Kim J, et al.
Mol Ther Methods Clin Dev
. 2020 May;
17:922-935.
PMID: 32405514
Improper activity of bone-resorbing osteoclasts results in low bone density and deterioration of bone structure, which increase the risk of fractures. Anti-resorptive therapies targeting osteoclasts have proven effective in preserving...