Sensors in Bone: Technologies, Applications, and Future Directions

Overview

Journal Sensors (Basel)

Publisher MDPI

Specialty Biotechnology

Date 2024 Oct 16

PMID 39409211

Authors

Afreen Anwar

Taruneet Kaur

Sachin Chaugule

Yeon-Suk Yang

Aryan Mago

Jae-Hyuck Shim

Aijaz Ahmad John

Affiliations

Soon will be listed here.

Abstract

Osteoporosis, a prevalent ailment worldwide, compromises bone strength and resilience, particularly afflicting the elderly population. This condition significantly heightens susceptibility to fractures even from trivial incidents, such as minor falls or impacts. A major challenge in diagnosing osteoporosis is the absence of discernible symptoms, allowing osteoporosis to remain undetected until the occurrence of a fracture event. Early symptom detection and swift diagnosis are critical for preventing severe issues related to bone diseases. Assessing bone turnover markers aids in identifying, diagnosing, and monitoring these conditions, guiding treatment decisions. However, conventional techniques for measuring bone mineral density are costly, time-consuming, and require specialized expertise. The integration of sensor technologies into medical practices has transformed how we monitor, diagnose, and treat various health conditions, including bone health and orthopedics. This review aims to provide a comprehensive overview of the current state of sensor technologies used in bone, covering their integration with bone tissue, various applications, recent advancements, challenges, and future directions.

References

Swaminathan R . Biochemical markers of bone turnover. Clin Chim Acta. 2001; 313(1-2):95-105. DOI: 10.1016/s0009-8981(01)00656-8. View

Tromp A, Ooms M, Popp-Snijders C, Roos J, Lips P . Predictors of fractures in elderly women. Osteoporos Int. 2000; 11(2):134-40. DOI: 10.1007/PL00004174. View

Parmar B, Longsine W, Sabonghy E, Han A, Tasciotti E, Weiner B . Characterization of controlled bone defects using 2D and 3D ultrasound imaging techniques. Phys Med Biol. 2010; 55(16):4839-59. DOI: 10.1088/0031-9155/55/16/014. View

Hart S, Eastell R . Biochemical markers of bone turnover. Curr Opin Nephrol Hypertens. 1999; 8(4):421-7. DOI: 10.1097/00041552-199907000-00005. View

Yang L, Grey V . Pediatric reference intervals for bone markers. Clin Biochem. 2006; 39(6):561-8. DOI: 10.1016/j.clinbiochem.2005.11.015. View

Wignarajah S, Suaifan G, Bizzarro S, Bikker F, Kaman W, Zourob M . Colorimetric Assay for the Detection of Typical Biomarkers for Periodontitis Using a Magnetic Nanoparticle Biosensor. Anal Chem. 2015; 87(24):12161-8. DOI: 10.1021/acs.analchem.5b03018. View

Zhao Y, Liu Y, Li Y, Hao Q . Development and Application of Resistance Strain Force Sensors. Sensors (Basel). 2020; 20(20). PMC: 7602478. DOI: 10.3390/s20205826. View

Naresh V, Lee N . A Review on Biosensors and Recent Development of Nanostructured Materials-Enabled Biosensors. Sensors (Basel). 2021; 21(4). PMC: 7915135. DOI: 10.3390/s21041109. View

Fukase N, Duke V, Lin M, Stake I, Huard M, Huard J . Wireless Measurements Using Electrical Impedance Spectroscopy to Monitor Fracture Healing. Sensors (Basel). 2022; 22(16). PMC: 9412277. DOI: 10.3390/s22166233. View

10.

Zhang J, Wang J, Tang J, Barnett B, Dickson J, Hahsimoto N . Bone sialoprotein promotes bone metastasis of a non-bone-seeking clone of human breast cancer cells. Anticancer Res. 2004; 24(3a):1361-8. View

11.

Nabavi N, Khandani A, Camirand A, Harrison R . Effects of microgravity on osteoclast bone resorption and osteoblast cytoskeletal organization and adhesion. Bone. 2011; 49(5):965-74. DOI: 10.1016/j.bone.2011.07.036. View

12.

Rani S, Bandyopadhyay-Ghosh S, Ghosh S, Liu G . Advances in Sensing Technologies for Monitoring of Bone Health. Biosensors (Basel). 2020; 10(4). PMC: 7235906. DOI: 10.3390/bios10040042. View

13.

Leung P, Pickarski M, Zhuo Y, Masarachia P, Duong L . The effects of the cathepsin K inhibitor odanacatib on osteoclastic bone resorption and vesicular trafficking. Bone. 2011; 49(4):623-35. DOI: 10.1016/j.bone.2011.06.014. View

14.

Crockett J, Rogers M, Coxon F, Hocking L, Helfrich M . Bone remodelling at a glance. J Cell Sci. 2011; 124(Pt 7):991-8. DOI: 10.1242/jcs.063032. View

15.

Shaban S, Moon B, Pyun D, Kim D . A colorimetric alkaline phosphatase biosensor based on p-aminophenol-mediated growth of silver nanoparticles. Colloids Surf B Biointerfaces. 2021; 205:111835. DOI: 10.1016/j.colsurfb.2021.111835. View

16.

Aydin S . A short history, principles, and types of ELISA, and our laboratory experience with peptide/protein analyses using ELISA. Peptides. 2015; 72:4-15. DOI: 10.1016/j.peptides.2015.04.012. View

17.

Perez-Castrillon J, Pinacho F, de Luis D, Lopez-Menendez M, Duenas Laita A . Odanacatib, a new drug for the treatment of osteoporosis: review of the results in postmenopausal women. J Osteoporos. 2010; 2010. PMC: 2951121. DOI: 10.4061/2010/401581. View

18.

Kim J, Campbell A, de Avila B, Wang J . Wearable biosensors for healthcare monitoring. Nat Biotechnol. 2019; 37(4):389-406. PMC: 8183422. DOI: 10.1038/s41587-019-0045-y. View

19.

Afsarimanesh N, Mukhopadhyay S, Kruger M . Molecularly Imprinted Polymer-Based Electrochemical Biosensor for Bone Loss Detection. IEEE Trans Biomed Eng. 2017; 65(6):1264-1271. DOI: 10.1109/TBME.2017.2744667. View

20.

Inal Kabala S, Yagar H, Ozcan H . A new biosensor for osteoporosis detection. Prep Biochem Biotechnol. 2019; 49(5):511-520. DOI: 10.1080/10826068.2019.1587628. View