Sabrin Albeituni
Overview
Explore the profile of Sabrin Albeituni including associated specialties, affiliations and a list of published articles.
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19
Citations
894
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Recent Articles
1.
Keenan C, Albeituni S, Nichols K, Hines M
Adv Exp Med Biol
. 2024 Aug;
1448:583-600.
PMID: 39117841
Cytokine storm syndromes (CSSs) comprise a group of severe and often fatal hyperinflammatory conditions driven by the overproduction of pro-inflammatory cytokines by activated cells of the immune system. Many of...
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Keenan C, Albeituni S, Oak N, Stroh A, Tillman H, Wang Y, et al.
Blood
. 2024 Mar;
143(23):2386-2400.
PMID: 38446698
Hemophagocytic lymphohistiocytosis (HLH) comprises a severe hyperinflammatory phenotype driven by the overproduction of cytokines, many of which signal via the JAK/STAT pathway. Indeed, the JAK1/2 inhibitor ruxolitinib has demonstrated efficacy...
4.
Bloom M, Oak N, Baskin-Doerfler R, Feng R, Iacobucci I, Baviskar P, et al.
Blood Adv
. 2023 Jul;
7(18):5608-5623.
PMID: 37522715
ETS variant 6 (ETV6) encodes a transcriptional repressor expressed in hematopoietic stem and progenitor cells (HSPCs), where it is required for adult hematopoiesis. Heterozygous pathogenic germline ETV6 variants are associated...
5.
Albeituni S, Oak N, Tillman H, Stroh A, Keenan C, Bloom M, et al.
Front Immunol
. 2023 May;
14:1137037.
PMID: 37228616
Background: Primary hemophagocytic lymphohistiocytosis (pHLH) is an inherited inflammatory syndrome driven by the exuberant activation of interferon-gamma (IFNg)-producing CD8 T cells. Towards this end, ruxolitinib treatment or IFNg neutralization (aIFNg)...
6.
Huarte E, Peel M, Verbist K, Fay B, Bassett R, Albeituni S, et al.
Front Pharmacol
. 2021 May;
12:650295.
PMID: 33981229
Hyperinflammatory syndromes comprise a heterogeneous group of disorders characterized by severe inflammation, multiple organ dysfunction, and potentially death. In response to antigenic stimulus (e.g., SARS-CoV-2 infection), overactivated CD8+ T-cells and...
7.
Keenan C, Nichols K, Albeituni S
Front Immunol
. 2021 Mar;
12:614704.
PMID: 33664745
Hemophagocytic lymphohistiocytosis (HLH) is a rare hyperinflammatory syndrome driven by overactive T cells and macrophages that abundantly secrete numerous pro-inflammatory cytokines, including interferon (IFN)-gamma, interleukin (IL)-1-beta, IL-2, IL-6, IL-10, IL-18,...
8.
Thomas A, Samykutty A, Gomez-Gutierrez J, Yin W, Egger M, McNally M, et al.
Cancers (Basel)
. 2020 Aug;
12(8).
PMID: 32823919
Pancreatic cancer remains a recalcitrant neoplasm associated with chemoresistance and high fatality. Because it is frequently resistant to apoptosis, exploiting autophagic cell death could offer a new treatment approach. We...
9.
Meyer L, Verbist K, Albeituni S, Scull B, Bassett R, Stroh A, et al.
Blood
. 2020 Jun;
136(6):657-668.
PMID: 32530039
Cytokine storm syndromes (CSS) are severe hyperinflammatory conditions characterized by excessive immune system activation leading to organ damage and death. Hemophagocytic lymphohistiocytosis (HLH), a disease often associated with inherited defects...
10.
Liu M, Tong Z, Ding C, Luo F, Wu S, Wu C, et al.
J Clin Invest
. 2020 Jan;
130(4):2081-2096.
PMID: 31945018
Macrophages have been linked to tumor initiation, progression, metastasis, and treatment resistance. However, the transcriptional regulation of macrophages driving the protumor function remains elusive. Here, we demonstrate that the transcription...