Katherine C Verbist
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Explore the profile of Katherine C Verbist including associated specialties, affiliations and a list of published articles.
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15
Citations
834
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0
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Recent Articles
1.
Sharma P, Guo A, Poudel S, Boada-Romero E, Verbist K, Palacios G, et al.
bioRxiv
. 2024 May;
PMID: 38798680
T cell receptor (TCR) engagement initiates the activation process, and this signaling event is regulated in multifaceted ways. Nutrient availability in the immediate niche is one such mode of regulation...
2.
Keenan C, Albeituni S, Oak N, Stroh A, Tillman H, Wang Y, et al.
Blood
. 2024 Mar;
143(23):2386-2400.
PMID: 38446698
Hemophagocytic lymphohistiocytosis (HLH) comprises a severe hyperinflammatory phenotype driven by the overproduction of cytokines, many of which signal via the JAK/STAT pathway. Indeed, the JAK1/2 inhibitor ruxolitinib has demonstrated efficacy...
3.
Bloom M, Oak N, Baskin-Doerfler R, Feng R, Iacobucci I, Baviskar P, et al.
Blood Adv
. 2023 Jul;
7(18):5608-5623.
PMID: 37522715
ETS variant 6 (ETV6) encodes a transcriptional repressor expressed in hematopoietic stem and progenitor cells (HSPCs), where it is required for adult hematopoiesis. Heterozygous pathogenic germline ETV6 variants are associated...
4.
Liedmann S, Liu X, Guy C, Crawford J, Rodriguez D, Kuzuoglu-Ozturk D, et al.
Mol Cell
. 2022 May;
82(13):2401-2414.e9.
PMID: 35597236
Activated CD8 T lymphocytes differentiate into heterogeneous subsets. Using super-resolution imaging, we found that prior to the first division, dynein-dependent vesicular transport polarized active TORC1 toward the microtubule-organizing center (MTOC)...
5.
Meyer L, Verbist K, Albeituni S, Scull B, Bassett R, Stroh A, et al.
Blood
. 2020 Jun;
136(6):657-668.
PMID: 32530039
Cytokine storm syndromes (CSS) are severe hyperinflammatory conditions characterized by excessive immune system activation leading to organ damage and death. Hemophagocytic lymphohistiocytosis (HLH), a disease often associated with inherited defects...
6.
Albeituni S, Verbist K, Tedrick P, Tillman H, Picarsic J, Bassett R, et al.
Blood
. 2019 Apr;
134(2):147-159.
PMID: 31015190
Hemophagocytic lymphohistiocytosis (HLH) is an often-fatal disorder characterized by the overactivation of T cells and macrophages that excessively produce proinflammatory cytokines, including interferon-γ (IFN-γ). Previously, we reported that the JAK...
7.
Verbist K, Guy C, Milasta S, Liedmann S, Kaminski M, Wang R, et al.
Nature
. 2016 Apr;
532(7599):389-93.
PMID: 27064903
Asymmetric cell division, the partitioning of cellular components in response to polarizing cues during mitosis, has roles in differentiation and development. It is important for the self-renewal of fertilized zygotes...
8.
Milasta S, Dillon C, Sturm O, Verbist K, Brewer T, Quarato G, et al.
Immunity
. 2016 Jan;
44(1):88-102.
PMID: 26795252
The role of apoptosis inducing factor (AIF) in promoting cell death versus survival remains controversial. We report that the loss of AIF in fibroblasts led to mitochondrial electron transport chain...
9.
Dillon C, Weinlich R, Rodriguez D, Cripps J, Quarato G, Gurung P, et al.
Cell
. 2014 May;
157(5):1189-202.
PMID: 24813850
Receptor-interacting protein kinase (RIPK)-1 is involved in RIPK3-dependent and -independent signaling pathways leading to cell death and/or inflammation. Genetic ablation of ripk1 causes postnatal lethality, which was not prevented by...
10.
Verbist K, Wang R, Green D
Semin Immunol
. 2013 Jan;
24(6):399-404.
PMID: 23313070
As T cells respond to pathogens, they must transition from a quiescent, naïve state, to a rapidly proliferating, active effector state, and back again to a quiescent state as they...