Sabitri Ghimire
Overview
Explore the profile of Sabitri Ghimire including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
15
Citations
406
Followers
0
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Recent Articles
1.
Nakanoh S, Sham K, Ghimire S, Mohorianu I, Rayon T, Vallier L
Sci Adv
. 2024 Mar;
10(9):eadh7748.
PMID: 38427729
Mechanisms specifying amniotic ectoderm and surface ectoderm are unresolved in humans due to their close similarities in expression patterns and signal requirements. This lack of knowledge hinders the development of...
2.
Schreiber V, Mercier R, Jimenez S, Ye T, Garcia-Sanchez E, Klein A, et al.
Mol Metab
. 2021 Aug;
53:101313.
PMID: 34352411
Objective: Mice lacking the bHLH transcription factor (TF) Neurog3 do not form pancreatic islet cells, including insulin-secreting beta cells, the absence of which leads to diabetes. In humans, homozygous mutations...
3.
Ghimire S, Mantziou V, Moris N, Martinez Arias A
Dev Biol
. 2021 Jan;
474:100-108.
PMID: 33484705
Technical and ethical limitations create a challenge to study early human development, especially following the first 3 weeks of development after fertilization, when the fundamental aspects of the body plan...
4.
Moris N, Anlas K, van den Brink S, Alemany A, Schroder J, Ghimire S, et al.
Nature
. 2020 Jun;
582(7812):410-415.
PMID: 32528178
The body plan of the mammalian embryo is shaped through the process of gastrulation, an early developmental event that transforms an isotropic group of cells into an ensemble of tissues...
5.
Piccand J, Vagne C, Blot F, Meunier A, Beucher A, Strasser P, et al.
Mol Metab
. 2019 Nov;
29:24-39.
PMID: 31668390
Objective: Enteroendocrine cells (EECs) of the gastro-intestinal tract sense gut luminal factors and release peptide hormones or serotonin (5-HT) to coordinate energy uptake and storage. Our goal is to decipher...
6.
Ghimire S, van der Jeught M, Neupane J, Roost M, Anckaert J, Popovic M, et al.
Sci Rep
. 2018 Apr;
8(1):5884.
PMID: 29650979
Mouse embryonic stem cells (mESCs) exist in a naive, primed and ground state of pluripotency. While comparative analyses of these pluripotency states have been reported, the mESCs utilized originated from...
7.
Neupane J, Ghimire S, Vandewoestyne M, Lu Y, Gerris J, Van Coster R, et al.
Cell Rep
. 2015 Nov;
13(7):1304-1309.
PMID: 26549459
Variation in the level of mtDNA heteroplasmy in adult tissues is commonly seen in patients with a mixture of wild-type and mutant mtDNA. A mixture of different mtDNA variants may...
8.
Duggal G, Warrier S, Ghimire S, Broekaert D, van der Jeught M, Lierman S, et al.
Stem Cells
. 2015 Jun;
33(9):2686-98.
PMID: 26108678
Human embryonic stem cells (hESCs) closely resemble mouse epiblast stem cells exhibiting primed pluripotency unlike mouse ESCs (mESCs), which acquire a naïve pluripotent state. Efforts have been made to trigger...
9.
van der Jeught M, Taelman J, Duggal G, Ghimire S, Lierman S, Chuva de Sousa Lopes S, et al.
Cell Reprogram
. 2015 Jun;
17(3):170-80.
PMID: 26053517
In mice, inhibition of both the fibroblast growth factor (FGF) mitogen-activated protein kinase kinase/extracellular-signal regulated kinase (MEK/Erk) and the Wnt signaling inhibitor glycogen synthase-3β (GSK3β) enables the derivation of mouse...
10.
Ghimire S, Heindryckx B, van der Jeught M, Neupane J, OLeary T, Lierman S, et al.
Stem Cells Dev
. 2014 Sep;
24(4):497-506.
PMID: 25245024
Early lineage segregation in preimplantation embryos and maintenance of pluripotency in embryonic stem cells (ESCs) are both regulated by specific signaling pathways. Small molecules have been shown to modulate these...