Sabine Borchard
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Explore the profile of Sabine Borchard including associated specialties, affiliations and a list of published articles.
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10
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428
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Recent Articles
1.
Borchard S, Raschke S, Zak K, Eberhagen C, Einer C, Weber E, et al.
Life Sci Alliance
. 2021 Dec;
5(3).
PMID: 34857647
In Wilson disease, excessive copper accumulates in patients' livers and may, upon serum leakage, severely affect the brain according to current viewpoints. Present remedies aim at avoiding copper toxicity by...
2.
Mulazzani M, Huber M, Borchard S, Langer S, Angele B, Schuh E, et al.
J Hematol Oncol
. 2019 Oct;
12(1):102.
PMID: 31615554
Background: Early diagnosis of CNS lymphoma (CNSL) is essential for successful therapy of this rapidly progressing brain tumor. However, in patients presenting with focal brain lesions, fast and reliable diagnosis...
3.
Einer C, Leitzinger C, Lichtmannegger J, Eberhagen C, Rieder T, Borchard S, et al.
Cell Mol Gastroenterol Hepatol
. 2018 Dec;
7(3):571-596.
PMID: 30586623
Background & Aims: In Wilson disease, ATP7B mutations impair copper excretion into bile. Hepatic copper accumulation may induce mild to moderate chronic liver damage or even acute liver failure. Etiologic...
4.
Polishchuk E, Merolla A, Lichtmannegger J, Romano A, Indrieri A, Ilyechova E, et al.
Gastroenterology
. 2018 Nov;
156(4):1173-1189.e5.
PMID: 30452922
Background & Aims: Wilson disease (WD) is an inherited disorder of copper metabolism that leads to copper accumulation and toxicity in the liver and brain. It is caused by mutations...
5.
Giorgi C, Marchi S, Simoes I, Ren Z, Morciano G, Perrone M, et al.
Int Rev Cell Mol Biol
. 2018 Aug;
340:209-344.
PMID: 30072092
Aging has been linked to several degenerative processes that, through the accumulation of molecular and cellular damage, can progressively lead to cell dysfunction and organ failure. Human aging is linked...
6.
Borchard S, Bork F, Rieder T, Eberhagen C, Popper B, Lichtmannegger J, et al.
Toxicol In Vitro
. 2018 May;
51:11-22.
PMID: 29715505
Wilson disease (WD) is characterized by a disrupted copper homeostasis resulting in dramatically increased copper levels, mainly in liver and brain. While copper damage to mitochondria is an established feature...
7.
Subramanian V, Borchard S, Azimzadeh O, Sievert W, Merl-Pham J, Mancuso M, et al.
J Proteome Res
. 2018 Mar;
17(4):1677-1689.
PMID: 29560722
High-dose ionizing radiation is known to induce adverse effects such as inflammation and fibrosis in the heart. Transcriptional regulators PPARα and TGFβ are known to be involved in this radiation...
8.
Einer C, Hohenester S, Wimmer R, Wottke L, Artmann R, Schulz S, et al.
Data Brief
. 2017 Oct;
15:163-169.
PMID: 29034285
The data presented in this article describe the fatty acid composition of chow, liver tissue and isolated liver mitochondria from mice fed for 6-24 weeks with a high caloric western...
9.
Einer C, Hohenester S, Wimmer R, Wottke L, Artmann R, Schulz S, et al.
Mitochondrion
. 2017 Sep;
40:1-12.
PMID: 28935446
Western lifestyle-associated malnutrition causes steatosis that may progress to liver inflammation and mitochondrial dysfunction has been suggested as a key factor in promoting this disease. Here we have molecularly, biochemically...
10.
Schmitt S, Saathoff F, Meissner L, Schropp E, Lichtmannegger J, Schulz S, et al.
Anal Biochem
. 2013 Aug;
443(1):66-74.
PMID: 23969012
Mitochondrial dysfunctions decisively contribute to the progression of human diseases, implying that functional tests of isolated mitochondria may furnish conclusive information for diagnosis and therapy. Classical mitochondrial isolation methods, however,...