» Articles » PMID: 29034285

Data on Chow, Liver Tissue and Mitochondrial Fatty Acid Compositions As Well As Mitochondrial Proteome Changes After Feeding Mice a Western Diet for 6-24 Weeks

Abstract

The data presented in this article describe the fatty acid composition of chow, liver tissue and isolated liver mitochondria from mice fed for 6-24 weeks with a high caloric western diet (WD) in comparison to control diet (normal diet, ND). The fatty acid composition was measured via gas chromatography flame ionization detection (GC-FID). Moreover, WD-induced mitochondrial protein changes are presented in this work and were analyzed by mass spectrometry (LC-MS/MS). For further interpretation and discussion of the presented data please refer to the research article entitled "Mitochondrial adaptation in steatotic mice" (Einer et al., 2017) [1].

Citing Articles

Var by-Products Prevent Lipid Accumulation and Cell Death in a Liver Cell Model of Lipid Toxicity.

Castelao-Baptista J, Valente S, Canario S, Oppolzer D, Barros A, Venancio C Nutrients. 2023; 15(4).

PMID: 36839282 PMC: 9965884. DOI: 10.3390/nu15040924.


Potential evidence for epigenetic biomarkers of metabolic syndrome in human whole blood in Latinos.

Urashima K, Miramontes A, Garcia L, Coletta D PLoS One. 2021; 16(10):e0259449.

PMID: 34714849 PMC: 8555810. DOI: 10.1371/journal.pone.0259449.


Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxicity on Human HepG2 Cells.

Amorim R, Simoes I, Veloso C, Carvalho A, Simoes R, Pereira F Nutrients. 2021; 13(5).

PMID: 34069635 PMC: 8161147. DOI: 10.3390/nu13051723.


IL-18 but Not IL-1 Signaling Is Pivotal for the Initiation of Liver Injury in Murine Non-Alcoholic Fatty Liver Disease.

Hohenester S, Kanitz V, Schiergens T, Einer C, Nagel J, Wimmer R Int J Mol Sci. 2020; 21(22).

PMID: 33202693 PMC: 7696705. DOI: 10.3390/ijms21228602.


Significance of Simple Steatosis: An Update on the Clinical and Molecular Evidence.

Mazzolini G, Sowa J, Atorrasagasti C, Kucukoglu O, Syn W, Canbay A Cells. 2020; 9(11).

PMID: 33187255 PMC: 7698018. DOI: 10.3390/cells9112458.


References
1.
von Toerne C, Kahle M, Schafer A, Ispiryan R, Blindert M, de Angelis M . Apoe, Mbl2, and Psp plasma protein levels correlate with diabetic phenotype in NZO mice--an optimized rapid workflow for SRM-based quantification. J Proteome Res. 2013; 12(3):1331-43. DOI: 10.1021/pr3009836. View

2.
Tetri L, Basaranoglu M, Brunt E, Yerian L, Neuschwander-Tetri B . Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent. Am J Physiol Gastrointest Liver Physiol. 2008; 295(5):G987-95. PMC: 4059366. DOI: 10.1152/ajpgi.90272.2008. View

3.
Folch J, Lees M, SLOANE STANLEY G . A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957; 226(1):497-509. View

4.
Kanehisa M, Sato Y, Kawashima M, Furumichi M, Tanabe M . KEGG as a reference resource for gene and protein annotation. Nucleic Acids Res. 2015; 44(D1):D457-62. PMC: 4702792. DOI: 10.1093/nar/gkv1070. View

5.
Schmitt S, Schulz S, Schropp E, Eberhagen C, Simmons A, Beisker W . Why to compare absolute numbers of mitochondria. Mitochondrion. 2014; 19 Pt A:113-23. DOI: 10.1016/j.mito.2014.06.005. View