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S Thoret

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Recent Articles
1.
El Sahili N, David-Tchouda S, Thoret S, Nasseh I, Berberi A, Fortin T
J Maxillofac Oral Surg . 2018 Oct; 17(4):520-530. PMID: 30344396
Background: Differences in CBCT units and the lack of standardization result in exposure to radiation doses beyond what is required for diagnostic purposes, especially when planning the surgical placement of...
2.
Gherbovet O, Sanchez-Murcia P, Garcia Alvarez M, Bignon J, Thoret S, Gago F, et al.
Org Biomol Chem . 2015 Jan; 13(10):3144-54. PMID: 25634805
Some hybrids of vinca alkaloids and phomopsin A, linked by a glycine pattern, have been synthesized in one or two steps, by an insertion reaction and shown to inhibit microtubule...
3.
Behar T, Bosson J, Galanaud J, Thoret S, Rolland C, Bura-Riviere A, et al.
J Mal Vasc . 2013 Jan; 38(1):22-8. PMID: 23352626
Background: Peripheral arterial disease (PAD) is an important predictor of cardiovascular disease with major medico-economic consequences. However, systematic screening of asymptomatic patients free from history of cardiovascular disease is debated....
4.
Merckle L, Dubois J, Place E, Thoret S, Gueritte F, Guenard D, et al.
J Org Chem . 2001 Jul; 66(15):5058-65. PMID: 11463257
Two novel 5(20)-thia analogues of docetaxel have been synthesized from 10-deacetylbaccatin III or taxine B and isotaxine B. The key step of these syntheses is the concomitant thietane ring formation...
5.
Roux D, Hadi H, Thoret S, Guenard D, Thoison O, Pais M, et al.
J Nat Prod . 2000 Sep; 63(8):1070-6. PMID: 10978200
Microtubule disassembly inhibitory properties have been established for the known polyisoprenylated benzophenones xanthochymol (1a) and guttiferone E (1b). The compounds were isolated from the fruits of Garcinia pyrifera collected in...
6.
Guenard D, Thoret S, Dubois J, Adeline M, Wang Q, Gueritte F
Bioorg Med Chem . 2000 Sep; 8(1):145-56. PMID: 10968273
Modifications of the hydrophobic character at the 7 and 10 positions of the taxoids greatly modified the effect of these drugs on the tubulin microtubule system. The presence of an...
7.
Brecht R, Seitz G, Guenard D, Thoret S
Bioorg Med Chem . 2000 Mar; 8(3):557-62. PMID: 10732972
Several B-ring variations of O-methyl androbiphenyline (8), newly accessible from (-)-(M,7S)-colchicine via photooxygenation and subsequent endoperoxide-transformation, were synthesized and evaluated for their inhibitory effects on tubulin assembly in vitro. The...
8.
Dupont C, Guenard D, Tchertanov L, Thoret S, Gueritte F
Bioorg Med Chem . 2000 Feb; 7(12):2961-9. PMID: 10658602
Novel (-)- and (+)-rhazinilam derivatives substituted on the D-ring (compounds 3, 4, 5 and 6) have been prepared from (+)-vincadifformine 7 and (-)-tabersonine and evaluated against the disassembly of microtubules...
9.
Poncet J, Hortala L, Busquet M, Thoret S, Pierre A, Atassi G, et al.
Bioorg Med Chem Lett . 1999 Jan; 8(20):2855-8. PMID: 9873636
A cyclic analog of the natural antiproliferative compound dolastatin 10 was synthesized by introducing an ester link between the N- and C-terminal residues which were modified accordingly. The final macrolactonization...
10.
Le H, Mayer M, Thoret S, Michelot R
Int J Pept Protein Res . 1995 Feb; 45(2):138-44. PMID: 7782161
Amino acid methyl dithioesters may be coupled in the presence of DMAP and salts to a growing peptide chain on a polymeric resin with high coupling yields and low racemization.