S S Watowich
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Explore the profile of S S Watowich including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
538
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Recent Articles
1.
Hegde S, Ni S, He S, Yoon D, Feng G, Watowich S, et al.
Oncogene
. 2009 Jul;
28(38):3349-59.
PMID: 19581930
Leukemogenesis requires two classes of mutations, one that promotes proliferation and one that blocks differentiation. The erythroleukemia induced by Friend virus is a multistage disease characterized by an early proliferative...
2.
Kubatzky K, Ruan W, Gurezka R, Cohen J, Ketteler R, Watowich S, et al.
Curr Biol
. 2001 Mar;
11(2):110-5.
PMID: 11231127
Hematopoietic cytokine receptors, such as the erythropoietin receptor (EpoR), are single membrane-spanning proteins. Signal transduction through EpoR is crucial for the formation of mature erythrocytes. Structural evidence shows that in...
3.
Watowich S, Mikami A, Busche R, Xie X, Pharr P, Longmore G
J Interferon Cytokine Res
. 2001 Jan;
20(12):1065-70.
PMID: 11152572
Erythropoietin (Epo) is essential for formation of mature red blood cells (RBC). However, the function of Epo receptor (EpoR)-dependent signaling pathways in the regulation of erythropoiesis remains unclear. To determine...
4.
Wooten D, Xie X, Bartos D, Busche R, Longmore G, Watowich S
J Biol Chem
. 2000 Jun;
275(34):26566-75.
PMID: 10858439
Hematopoietic cell development and function is dependent on cytokines and on intercellular interactions with the microenvironment. Although the intracellular signaling pathways stimulated by cytokine receptors are well described, little is...
5.
Cull V, Tilbrook P, Adenan A, Chappell D, Ingley E, Sarna M, et al.
Oncogene
. 2000 Mar;
19(7):953-60.
PMID: 10702804
J2E cells produce rapid, fatal erythroleukemias in vivo but still respond to erythropoietin (epo) in vitro by differentiating, proliferating and remaining viable in the absence of serum. Mutant epo receptors...
6.
Watowich S
Int J Biochem Cell Biol
. 1999 Dec;
31(10):1075-88.
PMID: 10582340
The hormone erythropoietin (Epo) is essential for red blood cell development. Epo binds a high affinity receptor on the surface of erythroid progenitor cells, stimulating receptor dimerization and activation of...
7.
Watowich S, Xie X, Klingmuller U, Kere J, Lindlof M, Berglund S, et al.
Blood
. 1999 Sep;
94(7):2530-2.
PMID: 10498627
Inherited mutations in the erythropoietin receptor (EPOR) causing premature termination of the receptor cytoplasmic region are associated with dominant familial erythrocytosis (FE), a benign clinical condition characterized by hypersensitivity of...
8.
Watowich S, Liu K, Xie X, Lai S, Mikami A, Longmore G, et al.
J Biol Chem
. 1999 Feb;
274(9):5415-21.
PMID: 10026152
Signal transduction by the erythropoietin receptor (EPOR) is activated by ligand-mediated receptor homodimerization. However, the relationship between extracellular and intracellular domain oligomerization remains poorly understood. To assess the requirements for...
9.
Levin I, Cohen J, Yoshimura A, Watowich S, Neumann D
FEBS Lett
. 1998 Jun;
427(2):164-70.
PMID: 9607304
Erythropoietin (EPO) promotes the viability, proliferation and differentiation of mammalian erythroid progenitor cells via its specific cell surface receptor. The EPO receptor (EPO-R) is a member of the cytokine receptor...
10.
Tarr K, Watowich S, Longmore G
J Biol Chem
. 1997 Apr;
272(14):9099-107.
PMID: 9083037
During erythroid development erythropoietin (EPO) binds specifically to a receptor primarily present on committed erythroid progenitors, stimulating mitogenic, survival, and differentiative growth response pathways. Other modes of erythropoietin receptor (EPO-R)...