R I Morimoto
Overview
Explore the profile of R I Morimoto including associated specialties, affiliations and a list of published articles.
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Articles
109
Citations
7883
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Recent Articles
1.
Mathew A, Mathur S, Jolly C, Fox S, Kim S, Morimoto R
Mol Cell Biol
. 2001 Oct;
21(21):7163-71.
PMID: 11585899
Vertebrate cells express a family of heat shock transcription factors (HSF1 to HSF4) that coordinate the inducible regulation of heat shock genes in response to diverse signals. HSF1 is potent...
2.
Ahn S, Liu P, Klyachko K, Morimoto R, Thiele D
Genes Dev
. 2001 Aug;
15(16):2134-45.
PMID: 11511544
Eukaryotic heat shock transcription factors (HSF) regulate an evolutionarily conserved stress-response pathway essential for survival against a variety of environmental and developmental stresses. Although the highly similar HSF family members...
3.
Holmberg C, Hietakangas V, Mikhailov A, Rantanen J, Kallio M, Meinander A, et al.
EMBO J
. 2001 Jul;
20(14):3800-10.
PMID: 11447121
Heat shock factor 1 (HSF1) is a serine-rich constitutively phosphorylated mediator of the stress response. Upon stress, HSF1 forms DNA-binding trimers, relocalizes to nuclear granules, undergoes inducible phosphorylation and acquires...
4.
Carr V, Menco B, Yankova M, Morimoto R, Farbman A
J Comp Neurol
. 2001 Mar;
432(4):425-39.
PMID: 11268007
Heat shock, or stress, proteins (HSPs) are induced in response to conditions that cause protein denaturation. Activation of cellular stress responses as a protective and survival mechanism is often associated...
5.
Song J, Takeda M, Morimoto R
Nat Cell Biol
. 2001 Mar;
3(3):276-82.
PMID: 11231577
Survival after stress requires the precise orchestration of cell-signalling events to ensure that biosynthetic processes are alerted and cell survival pathways are initiated. Here we show that Bag1, a co-chaperone...
6.
Thress K, Song J, Morimoto R, Kornbluth S
EMBO J
. 2001 Mar;
20(5):1033-41.
PMID: 11230127
Protein folding mediated by the Hsp70 family of molecular chaperones requires both ATP and the co-chaperone Hdj-1. BAG-1 was recently identified as a bcl-2-interacting, anti-apoptotic protein that binds to the...
7.
Jolly C, Morimoto R
J Natl Cancer Inst
. 2000 Oct;
92(19):1564-72.
PMID: 11018092
Exposure of cells to conditions of environmental stress-including heat shock, oxidative stress, heavy metals, or pathologic conditions, such as ischemia and reperfusion, inflammation, tissue damage, infection, and mutant proteins associated...
8.
Mosser D, Caron A, Bourget L, Meriin A, Sherman M, Morimoto R, et al.
Mol Cell Biol
. 2000 Sep;
20(19):7146-59.
PMID: 10982831
Cellular stress can trigger a process of self-destruction known as apoptosis. Cells can also respond to stress by adaptive changes that increase their ability to tolerate normally lethal conditions. Expression...
9.
Beere H, Wolf B, Cain K, Mosser D, Mahboubi A, Kuwana T, et al.
Nat Cell Biol
. 2000 Aug;
2(8):469-75.
PMID: 10934466
The cellular-stress response can mediate cellular protection through expression of heat-shock protein (Hsp) 70, which can interfere with the process of apoptotic cell death. Stress-induced apoptosis proceeds through a defined...
10.
Freeman B, Michels A, Song J, Kampinga H, Morimoto R
Methods Mol Biol
. 2000 Jul;
99:393-419.
PMID: 10909095
No abstract available.