G D Longmore
Overview
Explore the profile of G D Longmore including associated specialties, affiliations and a list of published articles.
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29
Citations
583
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Recent Articles
1.
Hadland B, Manley N, Su D, Longmore G, Moore C, Wolfe M, et al.
Proc Natl Acad Sci U S A
. 2001 Jun;
98(13):7487-91.
PMID: 11416218
A major therapeutic target in the search for a cure to the devastating Alzheimer's disease is gamma-secretase. This activity resides in a multiprotein enzyme complex responsible for the generation of...
2.
Watowich S, Mikami A, Busche R, Xie X, Pharr P, Longmore G
J Interferon Cytokine Res
. 2001 Jan;
20(12):1065-70.
PMID: 11152572
Erythropoietin (Epo) is essential for formation of mature red blood cells (RBC). However, the function of Epo receptor (EpoR)-dependent signaling pathways in the regulation of erythropoiesis remains unclear. To determine...
3.
Pharr P, Hofbauer A, Worthington R, Longmore G
Int J Hematol
. 2000 Oct;
72(2):178-85.
PMID: 11039666
Erythropoiesis is severely impaired in mice with inactivating mutations in the Steel factor (SF) gene (Sl/Sl mice) or in c-kit, in the SF receptor gene (W/W mice), and in mice...
4.
Kanungo J, Pratt S, Marie H, Longmore G
Mol Biol Cell
. 2000 Oct;
11(10):3299-313.
PMID: 11029037
Cellular adhesive events affect cell proliferation and differentiation decisions. How cell surface events mediating adhesion transduce signals to the nucleus is not well understood. After cell-cell or cell-substratum contact, cytosolic...
5.
Wooten D, Xie X, Bartos D, Busche R, Longmore G, Watowich S
J Biol Chem
. 2000 Jun;
275(34):26566-75.
PMID: 10858439
Hematopoietic cell development and function is dependent on cytokines and on intercellular interactions with the microenvironment. Although the intracellular signaling pathways stimulated by cytokine receptors are well described, little is...
6.
Beckman D, Lin L, Quinones M, Longmore G
Blood
. 1999 Oct;
94(8):2667-75.
PMID: 10515870
Erythropoietin (EPO) is required for the survival and expansion of red blood cell progenitor cells and supports continued differentiation of these committed progenitors to mature red blood cells. After binding...
7.
Goyal R, Longmore G
Ann Med
. 1999 Aug;
31(3):208-16.
PMID: 10442676
The production of erythroid cells is a dynamic and exquisitely regulated process. The mature red cell is only the final phase of a complex but orderly series of genetic events...
8.
Gaffen S, Lai S, Longmore G, Liu K, Goldsmith M
Blood
. 1999 Jun;
94(1):74-86.
PMID: 10381500
Erythropoietin (EPO) and its receptor (EPOR) are required for the development of mature erythrocytes. After binding of ligand, the EPOR activates a variety of signaling pathways that ultimately control cellular...
9.
Goyal R, Lin P, Kanungo J, Payne A, Muslin A, Longmore G
Mol Cell Biol
. 1999 May;
19(6):4379-89.
PMID: 10330178
LIM domain-containing proteins contribute to cell fate determination, the regulation of cell proliferation and differentiation, and remodeling of the cell cytoskeleton. These proteins can be found in the cell nucleus,...
10.
Watowich S, Liu K, Xie X, Lai S, Mikami A, Longmore G, et al.
J Biol Chem
. 1999 Feb;
274(9):5415-21.
PMID: 10026152
Signal transduction by the erythropoietin receptor (EPOR) is activated by ligand-mediated receptor homodimerization. However, the relationship between extracellular and intracellular domain oligomerization remains poorly understood. To assess the requirements for...