S P Arneric
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Explore the profile of S P Arneric including associated specialties, affiliations and a list of published articles.
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99
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1287
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Recent Articles
1.
Schroder H, Schutz U, Burghaus L, Lindstrom J, Kuryatov A, Monteggia L, et al.
Brain Res Dev Brain Res
. 2001 Dec;
132(1):33-45.
PMID: 11744105
Nicotinic acetylcholine receptors are likely to play an important role in neuronal migration during development. Furthermore, the alpha4 receptor subunit gene is related to a hereditary juvenile form of epilepsy....
2.
Takahashi L, Ho S, Livanov V, Graciani N, Arneric S
Brain Res
. 2001 Jun;
902(2):135-42.
PMID: 11384606
Two pharmacologically distinct CRF receptors are distributed in different brain regions and peripheral tissues. Studies suggest that CRF(1) receptors play an important role in mediating the anxiety provoking effects of...
3.
Ho S, Takahashi L, Livanov V, Spencer K, Lesher T, Maciag C, et al.
Brain Res Mol Brain Res
. 2001 Apr;
89(1-2):29-40.
PMID: 11311973
Corticotropin releasing factor (CRF) is an important regulator of the endocrine, behavioral, autonomic and immune responses to stress. Two high affinity CRF receptors have been identified, which are distributed in...
4.
Lin N, Li Y, He Y, Holladay M, Kuntzweiler T, Anderson D, et al.
Bioorg Med Chem Lett
. 2001 Mar;
11(5):631-3.
PMID: 11266158
In an effort to probe the steric influence of C5 substitution of the pyridine ring on CNS binding affinity, analogues of 1 substituted with a bulky moiety--such as phenyl, substituted...
5.
Seiffert D, Bradley J, Rominger C, Rominger D, Yang F, Meredith Jr J, et al.
J Biol Chem
. 2000 Aug;
275(44):34086-91.
PMID: 10915801
Presenilins are integral membrane protein involved in the production of amyloid beta-protein. Mutations of the presenilin-1 and -2 gene are associated with familial Alzheimer's disease and are thought to alter...
6.
Lin N, Abreo M, Gunn D, Lebold S, Lee E, Wasicak J, et al.
Bioorg Med Chem Lett
. 1999 Oct;
9(18):2747-52.
PMID: 10509928
Analogs of compound 1 with a variety of azacycles and heteroaryl groups were synthesized. These analogs exhibited Ki values ranging from 0.15 to > 10,000 nM when tested in vitro...
7.
Williams M, Kowaluk E, Arneric S
J Med Chem
. 1999 May;
42(9):1481-500.
PMID: 10229619
No abstract available.
8.
Briggs C, McKenna D, Monteggia L, Touma E, Roch J, Arneric S, et al.
Eur J Pharmacol
. 1999 Mar;
366(2-3):301-8.
PMID: 10082212
In the human alpha7 nicotinic receptor, valine-274 in the pore-lining transmembrane-2 region was mutated to threonine to produce the variant human alpha7V274T, which was evaluated electrophysiologically following expression in Xenopus...
9.
Holladay M, Bai H, Li Y, Lin N, Daanen J, Ryther K, et al.
Bioorg Med Chem Lett
. 1999 Jan;
8(19):2797-802.
PMID: 9873625
Analogs of A-98593 (1) and its enantiomer ABT-594 (2) with diverse substituents on the pyridine ring were prepared and tested for affinity to nicotinic acetylcholine receptor binding sites in rat...
10.
Lin N, Gunn D, Li Y, He Y, Bai H, Ryther K, et al.
Bioorg Med Chem Lett
. 1999 Jan;
8(3):249-54.
PMID: 9871663
Analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, (A-84543, 1) with 2-, 4-, 5-, and 6-substituents on the pyridine ring were synthesized. These analogs exhibited Ki values ranging from 0.15 to > 9,000 nM when...